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Polyomaviruses and Human Diseases
Science never solves apr oblem without creating ten more Geor ge Bernard Shaw How prophetic the above words prove to be when applied to the advances of 20th century medicine. Prior to Banting and Best, chnicians were unaware of the ravages of diabetes, patients simply wasted away and died. Following the purifica tion of insulin, clinicians now had to deal with diabetic retinopathy, diabetic neph ropathy and all the other complications of long-term diabetes. A little over 50 years ago, the first successful human kidney transplant was performed in Boston. The first 30 years of the experience had successes when compared to the alternative but were a constant struggle to get even 50% of the graf...
Chronic Allograft Failure
This book addresses one of the largest unmet needs in transplantation, the need to reduce late allograft loss. In the current era, it is reasonable to expect that most allografts will serve their recipients through their life span and death with preserved graft function the ultimate goal for all transplant recipients. However, long term allograft survival has not paralleled improvements made in short term survival. Each year a percentage of the existing organ transplant patients will lose their grafts. The problem of late allograft failure is due in part to pathogenic processes, to drug management, and to transplant patient care delivery. This book pulls together the science in this area and...
Renal Fibrosis
This publication provides a synopsis of the rapid progress made in the field of renal cell biology during the last decade, progress which has resulted in a better conceptual understanding of the cellular and molecular mechanisms of fibrotic renal disease. These developments have provided new therapeutic choices and led to the discovery of gene-based therapeutic options. The topics covered in this book have been carefully selected from the immense number of aspects of the disease to provide essential information on the molecular basis of renal fibrosis. Individual chapters discuss topics such as proteinuria and tubulointerstitial injury, the roles and regulation of TGF-beta, chemokines, oxidant stress, matrix remodeling, significance of renal expression of NF-kappa, and the potential impact of cell death in renal fibrosis.Written so as to present the complex information as simply as possible, this publication will be a very useful tool for general health professionals involved in the fields of immunology and cell biology, as well as for clinicians and researchers within the fields of nephrology, pathology and matrix biology.
Vitamin D
Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. Rickets among infants has reemerged. Low levels of vitamin D are associated with increased risk and mortality from cancer. At the same time, the beneficial effects of vitamin D on a host of conditions have recently been discovered. Focusing on areas not extensively covered in other comparable books, Vitamin D: Oxidative Stress, Immunity, and Aging highlights the most recent research findings on the impact of this nutrient in oxidative stress, immunity, and aging. A state-of-the-art compilation of essential information, this book explores: Vitamin D and its genomic and nongenom...
Climate Conflicts - A Case of International Environmental and Humanitarian Law
The book addresses the question of whether the currently available instruments of international environmental and international humanitarian law are applicable to climate conflicts. It clarifies the different pathways leading from climate change to conflict and offers an analysis of international environmental law embedded within the international doctrine of state responsibility. It goes on to discuss whether climate change amounts to an issue covered by Art. 2.4 UN Charter – the prohibition of the use of force. It then considers the possible application of international humanitarian law to climate conflicts. The book also offers a definition of the term “climate conflict”, drawing on legal as well as peace and conflict studies.
Handbook of Therapeutic Antibodies
Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.
Bartonella and Afipia Species Emphasizing Bartonella Henselae
An excellent beginning for the new Contributions in Microbiology series.... provides the definitive resource for any medical or scientific researcher interested in Bartonella and Afipia species or the etiology and pathology associated with catscratch fever disease... can be highly recommended as an addition to help complete any scientific library.
Ethnicity and Adivasi Identity in Bangladesh
This book explores the transitions in the adivasi identity as well as in the political representation of adivasi communities in Bangladesh. It traces the use of categories such as “primitive”, “tribe”, and “adivasi” in post-colonial Bangladesh, both in the political discourse and in everyday life. The volume studies the history of these essentialized categories used for indigenous communities within the hierarchies of power and identity. It also analyses the diverse articulations of indigeneity through ethnographic narratives, exploring the formations of newer traditions and identity. The author highlights the persistence of the terms “simple” and “primitive” in contemporary discourses while also sharing examples of complex mediations and appropriation of these categories by adivasi groups in Bangladesh. This book will be of interest to researchers and students of sociology, social ethnography, social and cultural anthropology, indigenous studies, exclusion studies, development studies, political sociology, and South Asian studies.
The 'Bedes' of Bengal
In the Bengali speaking regions of Bangladesh and India, the Bengali term bede today often evokes stereotypical imaginations of itinerant people. Of highly contested origin, the term has in the last two hundred years become the pivotal element for categorising and portraying diverse service nomads of the Bengal region. Besides an analysis of their portrayal in ethnographic and Bengali fictional literature, this book traces causes, reasons, and processes that have led to an increasing perception of these so-called `Bedes' as being ethnically different from the sedentary majority population.
Hypertension: from basic research to clinical practice
Hypertension: from basic research to clinical practice” contains a unique collection of selected chapters written by experts and enthusiasts engaged in research and treatment of hypertension, a condition that affects around a billion people in the world. The chapters describe fundamental researches at cellular and molecular levels to the science, and art of treatment of the condition in clinical practice. The topics included ranges from pathophysiology of hypertension, through monitoring of hypertension, to the treatment of hypertension in different patient categories. It contains essential background information as well as cutting edge research, and state of the art treatment alternatives in this broad field. From the beginners, and research students to the expert clinicians, and established scientists, everybody has something to learn from this book.
