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Cardiac Modeling: Aiming for Optimization of Therapy
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Computational Physiology
This open access volume compiles student reports from the 2023 Simula Summer School in Computational Physiology. The reports provide an overview of some tools available to model physiology in excitable tissues across scales and scientific questions. In 2023, Simula held the ninth annual Summer School in Computational Physiology in collaboration with the University of Oslo (UiO) and the University of California, San Diego (UCSD). Each year, the course focuses on modeling excitable tissues, with a special interest in cardiac physiology and neuroscience. Group research projects conducted by graduate students from around the world result in reports addressing problems of physiological importance. Reports may not necessarily represent new scientific results; rather, they can reproduce or supplement earlier studies. Reports from seven of the summer projects are included as separate chapters. The topics represented include multiscale mechanics, electrophysiology, pharmacology, and machine learning. This is an open access book.
Cardiac Defibrillation
The only known effective therapy for lethal disturbances in cardiac rhythm is de?brillation, the delivery of a strong electric shock to the heart. This technique constitutes the most important means for prevention of sudden cardiac death. The efficacy of defibrillation has led to an exponential growth in the number of patients receiving implantable devices. The objective of this book is to present contemporary views on the basic mechanisms by which the heart responds to an electric shock, as well as on the challenges and implications of clinical defibrillation. Basic science chapters elucidate questions such as lead configurations and the reasons by which a defibrillation shock fails. Chapters devoted to the challenges in the clinical procedure of defibrillation address issues related to inappropriate and unnecessary shocks, complications associated with the implantation of cardioverter/defibrillator devices, and the application of the therapy in pediatric patients and young adults. The book also examines the implications of defibrillation therapy, such as patient risk stratification, cardiac rehabilitation, and remote monitoring of patient with implantable devices.
Digital Twins in Medicine
Healthcare is at the dawn of a new era, and digital twins are playing a key role. The book Digital Twins in Medicine: Precision, Personalisation and the Future of Healthcare explores the ground-breaking possibilities of this technology, which has the ability to radically change the way we diagnose, treat and monitor disease. From personalised medicine, where treatment plans are tailored to the genetic and physiological characteristics of each patient, to precision surgery that minimises risk using virtual models of the human body, digital twins offer unprecedented precision in modern medicine. In oncology in particular, the technology enables the simulation of tumours to test the best therap...
Modeling the Heart and the Circulatory System
The book comprises contributions by some of the most respected scientists in the field of mathematical modeling and numerical simulation of the human cardiocirculatory system. The contributions cover a wide range of topics, from the preprocessing of clinical data to the development of mathematical equations, their numerical solution, and both in-vivo and in-vitro validation. They discuss the flow in the systemic arterial tree and the complex electro-fluid-mechanical coupling in the human heart. Many examples of patient-specific simulations are presented. This book is addressed to all scientists interested in the mathematical modeling and numerical simulation of the human cardiocirculatory system.
Cardiac Mapping
Cardiac Mapping is the cardiac electrophysiologist’s GPS. It will guide you to new places in the heart and help you find the old places more easily...a valuable addition to your bookshelf Douglas P. Zipes, from the Foreword. Over the course of three previous editions, this book has become the acknowledged gold standard reference on the electro-anatomical mapping of the heart. This new edition features greatly expanded coverage—the number of chapters have doubled to 80 with 40 new chapters—on leading edge science, new clinical applications and future frontiers, authored by a who’s-who of global electrophysiology. This unique text offers truly comprehensive coverage of all areas of car...
Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias
The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. Sudden cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while atrial fibrillation is the most common rhythm disorder; an arrhythmia that’s prevalence is increasing and accounts for nearly one quarter of ischemic stokes the elderly population. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising antiarrhythmic agents were found to increase rather than decrease mortality in patients recovering from myocardial infarction. The question t...
Cardiac Mechano-Electric Coupling and Arrhythmias
Ranging from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction, this new edition offers a thoroughly reviewed compendium of chapters, written by the top-experts in the world, on the mechanism and consequences of cardiac mechano-electrical coupling.
