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Cardiac Defibrillation
The only known effective therapy for lethal disturbances in cardiac rhythm is de?brillation, the delivery of a strong electric shock to the heart. This technique constitutes the most important means for prevention of sudden cardiac death. The efficacy of defibrillation has led to an exponential growth in the number of patients receiving implantable devices. The objective of this book is to present contemporary views on the basic mechanisms by which the heart responds to an electric shock, as well as on the challenges and implications of clinical defibrillation. Basic science chapters elucidate questions such as lead configurations and the reasons by which a defibrillation shock fails. Chapters devoted to the challenges in the clinical procedure of defibrillation address issues related to inappropriate and unnecessary shocks, complications associated with the implantation of cardioverter/defibrillator devices, and the application of the therapy in pediatric patients and young adults. The book also examines the implications of defibrillation therapy, such as patient risk stratification, cardiac rehabilitation, and remote monitoring of patient with implantable devices.
Computational Physiology
This open access volume compiles student reports from the 2023 Simula Summer School in Computational Physiology. The reports provide an overview of some tools available to model physiology in excitable tissues across scales and scientific questions. In 2023, Simula held the ninth annual Summer School in Computational Physiology in collaboration with the University of Oslo (UiO) and the University of California, San Diego (UCSD). Each year, the course focuses on modeling excitable tissues, with a special interest in cardiac physiology and neuroscience. Group research projects conducted by graduate students from around the world result in reports addressing problems of physiological importance. Reports may not necessarily represent new scientific results; rather, they can reproduce or supplement earlier studies. Reports from seven of the summer projects are included as separate chapters. The topics represented include multiscale mechanics, electrophysiology, pharmacology, and machine learning. This is an open access book.
Cardiac Modeling: Aiming for Optimization of Therapy
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Modeling the Heart and the Circulatory System
The book comprises contributions by some of the most respected scientists in the field of mathematical modeling and numerical simulation of the human cardiocirculatory system. The contributions cover a wide range of topics, from the preprocessing of clinical data to the development of mathematical equations, their numerical solution, and both in-vivo and in-vitro validation. They discuss the flow in the systemic arterial tree and the complex electro-fluid-mechanical coupling in the human heart. Many examples of patient-specific simulations are presented. This book is addressed to all scientists interested in the mathematical modeling and numerical simulation of the human cardiocirculatory system.
Conversations About Challenges in Computing
This text sheds light on how mathematical models and computing can help understanding and prediction of complicated physical processes; how communication networks should be designed and implemented to meet the increasingly challenging requirements from users; and how modern engineering principles can lead to better and more robust software systems. Through interviews with 12 internationally recognized researchers within these fields, conducted by the well-known science writer Dana Mackenzie and the science journalist Kathrine Aspaas, the reader gets views on recent achievements and future challenges.
High Performance Computing for Drug Discovery and Biomedicine
This volume explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. The first section collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. The second section delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced ...
Advances in Atrial Fibrillation Ablation, An Issue of Cardiac Electrophysiology Clinics
In collaboration with the Consulting Editors, Ranjan K. Thakur and Andrea Natale, Drs. Luigi Di Biase, Frank Marchlinski, and Andrea Natale have assembled an issue of Cardiac Electrophysiology Clinics on Advances in Atrial Fibrillation Ablation. Topics include, but are not limited to, Recurrent atrial fibrillation with isolated PVs, Beyond PVI in non paroxysmal atrial fibrillation, Recurrent atrial fibrillation after cryo, Recurrent atrial fibrillation after RF, high-density mapping, Expectation and Results of surrogate target beyond PVI, Lessons from epicardial mapping and ablation in refractory atrial fibrillation, Evolution of radiofrequency ablation parameters, Balloon based technologies, Energy sources, Current status of esophageal protection, Fluoroless atrial fibrillation ablation, Role of MRI imaging before and after ablation, When to stop OAC after atrial fibrillation ablation, Atrial fibrillation ablation trials, Risk Factor modification before and after atrial fibrillation ablation.
Cardiac Bioelectric Therapy
The updated and expanded second edition of this book presents a contemporary review of the basic science, engineering technology, and clinical practice of cardiac bioelectric therapy. It covers the rapidly expanding technological development of pacemakers and defibrillators as well as ablative therapy, electrophysiological mapping, and other clinical diagnostic and therapeutic breakthroughs. The book highlights many different aspects of bioelectric therapy, including history, biophysical and computational concepts, basic electrophysiology studies, engineering technology advances, and clinical perspectives. In this revised edition, leading clinical and basic electrophysiologists share their p...
AHA Scientific Sessions 2016: Program Information
The American Heart Association’s Scientific Sessions 2016 is bringing big science, big technology, and big networking opportunities to New Orleans, Louisiana this November. This event features five days of the best in science and cardiovascular clinical practice covering all aspects of basic, clinical, population and translational content.
