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The Kappa Opioid Receptor
This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds. It is divided up into the three parts: Molecular aspects of KOR, Preclinical research on pharmacology of KOR agonists and antagonists in animals and KOR agonists and antagonists in clinical use and in past and present clinical trials. The chapters "Biosensors monitor ligand-selective effects at kappa opioid receptors" and "The role of dynorphin and the kappa opioid receptor in schizophrenia and major depressive disorder: a translational approach" of this book are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
English as a Lingua Franca
English as a lingua franca has become a hot topic in Applied Linguistics and English Studies. While it has been a subject of controversy for some time, linguistic observations on actual use have largely been missing out of the debate. This is now changing fast, and the study of English as a lingua franca has become a vibrant research field. This book reflects achievements in the growing field; it presents a good selection of empirical findings, thus providing substance to arguments. It comprises contributions from pioneers and established scholars in the field, along with reports from substantial ongoing research projects. The papers offer insights into the workings of English as a lingua fr...
Handbook of Amygdala Structure and Function
Handbook of Amygdala Structure and Function, Volume 26, provides an updated overview on the functional neuroanatomy of amygdala nuclei, with an emphasis on interconnections (basolateral, central amygdala, medial amygdala) and their integration into related networks/circuits (prefrontal cortex, bed nucleus, nucleus accumbens). The design of this volume builds upon the foundations of functional neural circuits and the corresponding (cellular) electrophysiology important for the homeostatic control of amygdala function. This volume contains a dedicated section on the anatomical organization of the amygdala nuclei, emphasizing the role of neurotransmitters and neuropeptides that integrate signals and regulate behavior. Additional chapters discuss cellular physiology, plasticity and the integration of electrical signals that contribute to neural activity. The final section of the book connects the role of amygdala dysfunction and the development of disorders in human health and disease.
Application of Plant Secondary Metabolites to Pain Neuromodulation, Volume II
The importance of natural products and their metabolites in the treatment of pain and other diseases has been recognized by contemporary science, and a range of medications currently used in the clinic were indeed initially developed from natural products including medicinal plants. Historically, the mark of obtaining bioactive compounds with analgesic potential occurred in the 19th century when the first analgesic drugs obtained from medicinal plants were marketed. These included especially the opioids, such as morphine extracted from papaver (Papaver somniferum) and acetylsalicylic acid, which was synthesized from salicylic acid extracted from willow bark (Salix spp.). After almost two cen...
Mind Gym
Praise for Mind Gym "Believing in yourself is paramount to success for any athlete. Gary's lessons and David's writing provide examples of the importance of the mental game." --Ben Crenshaw, two-time Masters champion and former Ryder Cup captain "Mind Gym hits a home run. If you want to build mental muscle for the major leagues, read this book." --Ken Griffey Jr., Major League Baseball MVP "I read Mind Gym on my way to the Sydney Olympics and really got a lot out of it. Gary has important lessons to teach, and you'll find the exercises fun and beneficial." --Jason Kidd, NBA All-Star and Olympic gold-medal winner In Mind Gym, noted sports psychology consultant Gary Mack explains how your mind influences your performance on the field or on the court as much as your physical skill does, if not more so. Through forty accessible lessons and inspirational anecdotes from prominent athletes--many of whom he has worked with--you will learn the same techniques and exercises Mack uses to help elite athletes build mental "muscle." Mind Gym will give you the "head edge" over the competition.
The Guardian Index
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Endogenous Opioids
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