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A Primate Model for the Study of Colitis and Colonic Carcinoma The Cotton-Top Tamarin (Saguinus oedipus)
A Primate Model for the Study of Colitis and Colonic Carcinoma describes recent observations of the prevalence, pathogenesis, natural history, and time-course of idiopathic colitis and colonic carcinoma in the Cotton-Top Tamarin (CTT) model. Results of colonoscopy and mucosal biopsy are shown to evaluate the therapeutic efficacy of new anti-colitic agents. The contributions of antigenic profiles as a function of disease state, occurrence of extra-intestinal manifestations, and possible causal agents of colitis are also discussed. Prevalence of spontaneous CTT colonic carcinoma is considered from genetic influence, from promotion by colitis, and through the use of diagnostic and prognostic tools such as flow cytometry. Changes in fecal steroids, serum markers, colonic glycoprotein, polyamine metabolism, and immunobiology of CTTs are discussed in regard to disease condition. The book is an essential reference on the CTT model for gastroenterologists, oncologists, and all researchers interested in digestive diseases.
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Biology and Treatment of Colorectal Cancer Metastasis
The theme of the current workshop was identified several years ago and was considered by the working group of the National Large Bowel Cancer Project to be an appropriate workshop topic. Although the subject was important then, it was not possible to conduct such a workshop at that time. In the interim, not only did the problems associated with colorectal metastasis still exist, but new insights on the biology and treatment of colorectal cancer metastasis emerged, making the workshop topic especially important and relevant. With input from an expert Planning Committee, a unique program was designed to provide an opportunity for information exchange between basic scientists and clinical investigators. The published proceedings reflect the organization of the workshop which consisted of five sections: Section I. The Biology of Colorectal Cancer Metastasis co-chaired by Drs. J. Isaiah Fidler and George Poste Controversies in the Management of Patients with Colorectal Cancer Section II.
