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Molecular Targets and Therapeutic Interventions Against Neurodegenerative Diseases
  • Language: en
  • Pages: 300

Molecular Targets and Therapeutic Interventions Against Neurodegenerative Diseases

  • Type: Book
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  • Published: 2025-03-31
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  • Publisher: CRC Press

This book comprehensively explores the latest advancements in the understanding, diagnosis, and treatment of neurodegenerative diseases. The chapters provide an in-depth review of current approaches and treatment strategies for Alzheimer's disease, offering insights into the latest developments and breakthroughs. It also reviews the cutting-edge research on potential novel targets for Alzheimer's pharmacotherapy, with a focus on JNK3, GSK3β, and Fyn kinase inhibitors, providing an update on related approaches and their implications. It discusses the potential of ethnomedicines as a promising tool for mitigating Alzheimer's disease, offering insights into traditional remedies and their moder...

Proteases in Health and Disease
  • Language: en
  • Pages: 407

Proteases in Health and Disease

In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.

Deciphering Drug Targets for Alzheimer’s Disease
  • Language: en
  • Pages: 388

Deciphering Drug Targets for Alzheimer’s Disease

This book explains the fundamental characteristics and biofunctionality of Alzheimer’s Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimer’s Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimer’s disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimer’s disease treatment.

Studies in Natural Products Chemistry
  • Language: en
  • Pages: 562

Studies in Natural Products Chemistry

  • Type: Book
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  • Published: 2018-08-31
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  • Publisher: Elsevier

Studies in Natural Products Chemistry, Volume 59, the latest in the series, covers the synthesis, or testing and recording, of the medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, this book is a welcomed resource. - Focuses on the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - Presents sources of new pharmacophores

Viral Polymerases
  • Language: en
  • Pages: 498

Viral Polymerases

Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets presents in-depth study information on the structure and functions of polymerases and their roles in the lifecycle of viruses, and as drug targets. Viral polymerases constitute a vital component in the lifecycle of many viruses, such as human immunodeficiency virus (HIV), hepatitis viruses, influenza virus, and several others. They are essentially required for the replication of viruses. Thus, the polymerases that can be found in viruses (called viral polymerases) represent favorable targets for the design and development of antiviral drugs. - Provides comprehensive, state-of-the-art coverage on virus infections, the virus lifecycle, and mechanisms of polymerase inhibition - Analyzes the structure-activity relationships of inhibitors of each viral polymerase - Presents a consistent and comprehensive coverage of all aspects of viral polymerases, including structure, function and their role as antiviral drug targets

Gulf Business
  • Language: en
  • Pages: 706

Gulf Business

  • Type: Book
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  • Published: 2008
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  • Publisher: Unknown

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Sulfonamides
  • Language: en
  • Pages: 359

Sulfonamides

"This book presents comprehensive accounts of the chemistry revolving around the sulphonamides. Sulfonamides are widely present in various drugs as a functional group and are a manmade synthetic drug. Hence, their extended research is a prerequisite for every practitioner of organic chemistry. Chapter 1 introduces the synthesis, reactivity, acidity, and pharmaceutical properties of the sulphonamides. It highlights the synthesis of biologically active sulphonamides, the study of their biological activity by QSAR method, and their medical applications. Chapter 2 deals with the classification of sulphonamides (i.e. acyclic and cyclic) and their structural activity relationship. It also describe...

WEBKDD 2002 - Mining Web Data for Discovering Usage Patterns and Profiles
  • Language: en
  • Pages: 190

WEBKDD 2002 - Mining Web Data for Discovering Usage Patterns and Profiles

  • Type: Book
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  • Published: 2003-10-02
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  • Publisher: Springer

1 WorkshopTheme Data mining as a discipline aims to relate the analysis of large amounts of user data to shed light on key business questions. Web usage mining in particular, a relatively young discipline, investigates methodologies and techniques that - dress the unique challenges of discovering insights from Web usage data, aiming toevaluateWebusability,understandtheinterestsandexpectationsofusersand assess the e?ectiveness of content delivery. The maturing and expanding Web presents a key driving force in the rapid growth of electronic commerce and a new channel for content providers. Customized o?ers and content, made possible by discovered knowledge about the customer, are fundamental f...

Biodegradable Polymers in Clinical Use and Clinical Development
  • Language: en
  • Pages: 594

Biodegradable Polymers in Clinical Use and Clinical Development

This book focuses on biodegradable polymers that are already in clinical use or under clinical development. Synthetic and natural polymers will be included. This excludes polymers that have been investigated and did not reach clinical development. The purpose of this book is to provide updated status of the polymers that are clinical use and those that are now being developed for clinical use and hopefully will reach the clinic during the next 5 years. The book provides information that of interest to academics and practicing researchers including chemists, biologists and bioengineers and users: physicians, pharmacists.

Focus On: 100 Most Popular Canadian Male Film Actors
  • Language: en
  • Pages: 889

Focus On: 100 Most Popular Canadian Male Film Actors

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