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Genes, Chromosomes, and Disease
This very readable overview of the rise and transformations of medical genetics and of the eugenic impulses that have been inspired by the emerging understanding of the genetic basis of many diseases and disabilities is based on a popular nonmajors course, "Social Implications of Genetics," that Gillham gave for many years at Duke University. The book is suitable for use as a text in similar overview courses about genes and social issues or genes and disease. It gives a good overview of the developments and status of this field for a wide range of biomedical researchers, physicians, and students, especially those interested in the prospects for the new, genetics-based personalized medicine.
A Life of Sir Francis Galton
This vivid biography of the father of eugenics is also a superb portrait of science in the Victorian era. 10 halftones & 26 line illustrations.
A Life of Sir Francis Galton
Few scientists have made lasting contributions to as many fields as Francis Galton. He was an important African explorer, travel writer, and geographer. He was the meteorologist who discovered the anticyclone, a pioneer in using fingerprints to identify individuals, the inventor of regression and correlation analysis in statistics, and the founder of the eugenics movement. Now, Nicholas Gillham paints an engaging portrait of this Victorian polymath. The book traces Galton's ancestry (he was the grandson of Erasmus Darwin and the cousin of Charles Darwin), upbringing, training as a medical apprentice, and experience as a Cambridge undergraduate. It recounts in colorful detail Galton's adventu...
Organelle Genes and Genomes
Here is an exhaustive exploration of all aspects of research on organelle genomes. This outstanding new volume reviews the properties of chloroplast and mitorchondrial genomes, describing in depth their structure, gene content, expression, evolution, and genetics. The book takes readers to the outer limits of contemporary research, showing how the study of genomes contributes to the solution of important problems in molecular biology. It covers a wide range of problems from the use of organelle DNA molecules in taxonomic and phylogenetic studies to molecular investigations of the mechanisms underlying RNA editing, intron splicing and mobility, protein import, and mitochondrial disease. This unique text is designed for an introductory course in organelle genetics at the graduate or advanced undergraduate level. It is of special interest to professionals in the fields of molecular and cell biology, genetics, and evolution.
Organelle Heredity
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Hereditary Genius
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The Molecular Biology of Chloroplasts and Mitochondria in Chlamydomonas
Provides a thorough overview of current research with the green alga Chlamydomonas on chloroplast and mitochondrial biogenesis and function, with an emphasis on the assembly and structure-function relationships of the constituents of the photosynthetic apparatus. Contributions emphasize the multidisciplinary nature of current research in photosynthesis, combining molecular genetics, biochemical, biophysical, and physiological approaches. The 36 articles address topics including nuclear genome organization; RNA stability and processing; splicing; translation; protein targeting in the chloroplast; photosystems; pigments; glycerolipids; the ATP synthase; and ferrodoxin and thioredoxin. Further contributions address new measurements methods for photosynthetic activity in vivo; starch biosynthesis; the responses of Chlamydomonas to various stress conditions; nitrogen assimilation; and mitochondrial genetics. Annotation copyrighted by Book News, Inc., Portland, OR
Extrachromosomal DNA
Extrachromosomal DNA contains the proceedings of the 1979 ICN-UCLA Symposia on Molecular and Cellular Biology held in Keystone, Colorado. Contributors focus on extrachromosomal DNA, paying particular attention to the biogenesis of yeast mitochondria. They discuss topics based on the premise that the diversity and complexity of primitive mitochondrial and perhaps chloroplast DNA structure and replication have more in common with many viral systems than with either prokaryotic or eukaryotic systems. This is especially striking in the case of so-called split genes. This book is organized into nine sections encompassing 34 chapters and begins with an overview of extranuclear genetics and the evo...
Cell Organelles
The compartmentation of genetic information is a fundamental feature of the eukaryotic cell. The metabolic capacity of a eukaryotic (plant) cell and the steps leading to it are overwhelmingly an endeavour of a joint genetic cooperation between nucleus/cytosol, plastids, and mitochondria. Alter ation of the genetic material in anyone of these compartments or exchange of organelles between species can seriously affect harmoniously balanced growth of an organism. Although the biological significance of this genetic design has been vividly evident since the discovery of non-Mendelian inheritance by Baur and Correns at the beginning of this century, and became indisputable in principle after Renn...
