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Mitochondria are tiny structures located inside our cells that carry out the essential task of producing energy for the cell. They are found in all complex living things, and in that sense, they are fundamental for driving complex life on the planet. But there is much more to them than that. Mitochondria have their own DNA, with their own small collection of genes, separate from those in the cell nucleus. It is thought that they were once bacteria living independent lives. Their enslavement within the larger cell was a turning point in the evolution of life, enabling the development of complex organisms and, closely related, the origin of two sexes. Unlike the DNA in the nucleus, mitochondri...
Oxygen offers fresh perspectives on our own lives and deaths, explaining modern killer diseases, why we age, and what we can do about it. Advancing revelatory new ideas, following chains of evidence, the book ranges through many disciplines, from environmental sciences to molecular medicine. Damage to DNA caused by oxidative stress appears to explain aging and many of its diseases, hence the popularity in alternative health circles of antioxidants. But antioxidants alone fail to prevent aging. Lane suggests two different avenues of study: modulation of the immune system, which generates free radicals as part of its defense against infectious diseases; and ways of improving the health of our cellular mitochondria, on which many age-related ailments seem to depend. Provocative and complexly argued. Copyright ©Kirkus Reviews, used with permission.
Winner of the 2010 Royal Society Prize for science books Powerful new research methods are providing fresh and vivid insights into the makeup of life. Comparing gene sequences, examining the atomic structure of proteins and looking into the geochemistry of rocks have all helped to explain creation and evolution in more detail than ever before. Nick Lane uses the full extent of this new knowledge to describe the ten greatest inventions of life, based on their historical impact, role in living organisms today and relevance to current controversies. DNA, sex, sight and consciousnesses are just four examples. Lane also explains how these findings have come about, and the extent to which they can be relied upon. The result is a gripping and lucid account of the ingenuity of nature, and a book which is essential reading for anyone who has ever questioned the science behind the glories of everyday life.
A game-changing book on the origins of life, called the most important scientific discovery 'since the Copernican revolution' in The Observer.
'One of my favourite science writers' Bill Gates 'Hugely important' Jim Al-Khalili 'A profound meditation on metabolism, the Krebs cycle & the origin of life' Anil Seth For decades, biology has been dominated by information - the power of genes. Yet there is no difference in information content between a living cell and one that died a moment ago. A better question goes back to the formative years of biology: what processes animate cells and set them apart from lifeless matter? In Transformer, Nick Lane turns the standard view upside down, capturing an extraordinary scientific renaissance that is hiding in plain sight. At its core is an amazing cycle of reactions that uses energy to transform inorganic molecules into the building blocks of life - and the reverse. To understand this cycle is to fathom the deep coherence of the living world. It connects the origin of life with the devastation of cancer, the first photosynthetic bacteria with our own mitochondria, sulphurous sludges with the emergence of consciousness, and the trivial differences between ourselves with the large-scale history of our planet.
While it is barely 50 years since the first reliable reports of the recovery of living cells frozen to cryogenic temperatures, there has been tremendous growth in the use of cryobiology in medicine, agriculture, horticulture, forestry, and the conservation of endangered or economically important species. As the first major text on cryobiolog
'I love you. I'm sorry for what I did to you. I'm going to write it all down, explain everything that happened, why I broke your heart, and then I'm going to email it to you. I will be waiting for you at 5 p.m. Friday by the windmill hole at the crazy golf at the Pier where we played once. If you still want me then, when you're done reading this, come and get me. OK? Consider this the most screwed up love letter ever.' So begins Nick Lake's brilliant tour de force romance which introduces readers to Cassie, a New Jersey Shore teen who, over the course of one summer, experiences the exhilarating highs of new love, the frightening free falls of personal demons and family tragedy, and the bumps along the way to forgiveness, acceptance, and self-discovery. Told entirely through flashbacks, readers will savour every moment of Cassie's relationship with a boardwalk boy and race to the last page to discover how it all ends.
This account describes the author's adventures during an 18-month journey beyond forbidden frontiers in Asia. With minimal equipment and disguised as an itinerant Muslim, he hitch-hiked and walked through southern Turkey, and the Iran of the Ayatollahs, entering Afghanistan illegally in the wake of a convoy of Chinese weapons and then spent months dodging Russian helicopter gunships with the rebel guerillas. He was the first foreigner to cross from Pakistan into the closed western province of China since the revolution on 1949.
'An utter joy . . . wonderfully skilled' Sarah Perry 'Riveting, twisty, page-turning stuff' Guardian 'Beguiling, brilliantly creepy, and an utterly compelling read' Claire Fuller When the eight-year-old daughter of an Oxford College Master vanishes in the middle of the night, police turn to the Scottish nanny, Dee, for answers. As Dee looks back over her time in the Master's Lodging - an eerie and ancient house - a picture of a high achieving but dysfunctional family emerges: Nick, the fiercely intelligent and powerful father; his beautiful Danish wife Mariah, pregnant with their child; and the lost little girl, Felicity, almost mute, seeing ghosts, grieving her dead mother. But is Dee telli...
From the author of the #1 bestselling The Atlantis Gene comes a new novel in which the world’s past and future rests in the hands of five unwitting strangers in this definitive edition of A. G. Riddle's time-traveling, mind-bending speculative thriller. En route to London from New York, Flight 305 suddenly loses power and crash-lands in the English countryside, plunging a group of strangers into a mysterious adventure that will have repercussions for all of humankind. Struggling to stay alive, the survivors soon realize that the world they’ve crashed in is very different from the one they left. But where are they? Why are they here? And how will they get back home? Five passengers seem t...