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Complement in Nervous System Disease
Neuroinflammation is associated with a wide spectrum of acute and chronic diseases of the central and peripheral nervous system. It causes secondary damage, which is a major determinant for progression and outcome. Activated complement is suspected to be a key player to neuroinflammation. Complement is an important evolutionary ancient system for host anti-microbial aid. It serves the innate immunity and interfaces with the adaptive immunity. Complement recognizes non-cognate or altered-self antigens and devours 'unwanted' cells or cell compartments. Activation of complement leads to opsonisation of a target, inflammation by the release of anaphylatoxins, and damage of the target by the assembled membrane attack complex. Because complement can harm self-tissue, activation is tightly controlled by regulators. However, complement activation might be excessive and uncontrolled at sites of damage contributing to neuroinflammation leading to neurodegeneration.
The Promise of Low Dose Naltrexone Therapy
Naltrexone is an opiate antagonist drug developed in the 1970s and approved by the FDA in 1984 for opiate and drug abuse treatment. When used at much lower doses in an off-label protocol referred to as low dose naltrexone (LDN), the drug has been shown to halt disease progression in Crohn's disease and certain cancers, to reduce symptoms in multiple sclerosis and autism, and to improve numerous autoimmune and neurodegenerative conditions, including Parkinson's disease and amyotrophic lateral sclerosis (ALS). Grounded in clinical and scientific research, this book describes the history of naltrexone, its potential therapeutic uses, its effects on the immune system, its pharmacological properties, and how the drug is administered. It also lists fillers and compounding pharmacies, doctors who prescribe LDN, and patient resources, and includes interviews with LDN patients and researchers.
Post-Fire Management and Restoration of Southern European Forests
In spite of all the efforts made in fire prevention and suppression, every year about 45 000 forest fires occur in Europe, burning ca. 0.5 million hectares of forests and other rural lands. The management of these burned forests has been given much less attention than fire prevention or fire suppression issues, but the post-fire management of burned areas raises strong concerns (economic and social impacts, soil erosion and water quality, biodiversity loss, forest restoration). Although there are a few publications which address post-fire management, the focus of these has been either on general approaches to restoration or specific topics such as preventing post-fire soil erosion. This book is about the post-fire management of fire-prone forest types in southern Europe. It provides the first comprehensive overview of the topic, ranging from stand-level to landscape-level management, and from emergency actions to long-term restoration approaches.
Health 4.0: How Virtualization and Big Data are Revolutionizing Healthcare
This book describes how the creation of new digital services—through vertical and horizontal integration of data coming from sensors on top of existing legacy systems—that has already had a major impact on industry is now extending to healthcare. The book describes the fourth industrial revolution (i.e. Health 4.0), which is based on virtualization and service aggregation. It shows how sensors, embedded systems, and cyber-physical systems are fundamentally changing the way industrial processes work, their business models, and how we consume, while also affecting the health and care domains. Chapters describe the technology behind the shift of point of care to point of need and away from ...
Trade Marks and Free Trade
This book is the first study to examine the issue of the legality of parallel imports of trademarked goods under the most important legal systems on an international level, namely under GATT/WTO law, EU law and the laws of the ten major trading partners of the European Union. Part I consists of a general approach to the phenomenon of parallel importation and of a presentation of the theories that have been suggested to resolve the above-mentioned issue. The rule of exhaustion of rights, of which there are three types (rule of national, regional and international exhaustion of rights), is proposed as the most effective instrument to deal with the issue in question. Part II examines the questi...
Alzheimer's Disease in the Middle-aged
Dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. The most common form of dementia among older people is Alzheimer's disease (AD), which involves the parts of the brain that control thought, memory, and language. Age is the most important known risk factor for AD. The number of people with the disease doubles every 5 years beyond age 65. AD is a slow disease, starting with mild memory problems and ending with severe brain damage. The course the disease takes and how fast changes occur vary from person to person. On average, AD patients live from 8 to 10 years after they are diagnosed, though the disease can last for as many as 20 years. Cur...
Neonatal Care
This up-to-the-minute work is set against the backdrop of remarkable advances in Neonatal care. Including selected updates of contemporary issues concerning basic research and clinical practice, the present book investigates pathogenetic mechanisms implicated in fetal brain injury, sleep apnea, as well as covering the field of neonatal gastroenterology and nutrition care. It stimulates further research by fully acquainting the reader with the current knowledge and future perspectives in the sphere of an epidemiologic study for low birthweight, and the introduction of an effective, evidence-based innovational newborn program of care. Multidisciplinary specialists in Neonatology will find this book to be an essential resource, fundamental for a successful neonatal outcome.
Neuroimmune System
The book explores the intricate connections between the nervous and immune systems in the context of neurodegenerative disorders, offering a comprehensive overview of the bidirectional communication between these systems and their implications for disease progression and therapeutic interventions. The book aims to understand the recent developments in the field of neuroimmune communication. Key Features: In-depth analysis of immunological biomarkers and therapeutic targets for neurodegenerative disorders. Exploration of the role of glial cells in neuroimmune interactions and their dual nature in disease pathology. Examination of short- and long-range interactions between the central nervous ...
The Stem Cell Epistles
Human embryos, it has been said, "have no muscles, nerves, digestive system, feet, hands, face, or brain; they have nothing to distinguish them as a human being, and if one of them died, no one would mourn as they would for one of us." Consequently, early human embryos are being dismembered in laboratories around the world to produce embryonic stem cells, which, we are told, are the tools that will lead to the next quantum leap in medicine. Should Christians support such small sacrifices for something that might potentially relieve the suffering of millions, or should we vigorously oppose it? Developmental biologist and professor of biochemistry Michael Buratovich was asked such a question (...
