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Therapeutic potential of natural products in oxidative and metabolic diseases
Oxidative and metabolic diseases represent a large proportion of global challenges to health and quality of life. These diseases are often characterised by the imbalance between the cellular prooxidant (products of metabolic processes) and the antioxidant molecules within the cells. The imbalance often led to the underlying factors that exacerbate the pathogenesis of some life-threatening diseases such as carcinogenesis, obesity, diabetes, and cardiovascular diseases. Natural products, including phytochemicals and functional foods are known for their ability to affect metabolic processes such as ameliorating reactive oxygen species-induced mitochondria dysfunction, mitigating inflammatory response, and other cellular functions that could ameliorate the disease developments. Despite the relatively low toxicities of natural products as compared with synthetic products, further studies are still required to optimize the bioavailability, therapeutics, pharmaceutics, and clinical trials of natural products in patients suffering oxidative and metabolic diseases.
Antidiabetic Medicinal Plants
Medicinal Plants with Antidiabetic Properties: Applications and Opportunities is the first comprehensive reference to present the state of current research as well as those developments that are impacting developments in the use of plants to address diabetic conditions. Presenting multiple perspectives on the plants, their identification, cultivation and application, this book presents the state of the art with an eye toward the future. Herbal drugs and their components with insignificant toxicity and limited or no side effects are valuable therapeutic alternatives in the treatment of diabetes around the world and have been considered a fundamental source of potent antidiabetic drugs. Explor...
Ethnopharmacology
Ethnopharmacology is one of the world’s fastest-growing scientific disciplines encompassing a diverse range of subjects. It links natural sciences research on medicinal, aromatic and toxic plants with socio-cultural studies and has often been associated with the development of new drugs. The Editors of Ethnopharmacology have assembled an international team of renowned contributors to provide a critical synthesis of the substantial body of new knowledge and evidence on the subject that has emerged over the past decade. Divided into three parts, the book begins with an overview of the subject including a brief history, ethnopharmacological methods, the role of intellectual property protectio...
Mycotoxin and Food Safety in Developing Countries
This book provides information on the incidence of fungi and mycotoxins in some African countries, the health implications and possible intervention control strategies for mycotoxins in developing countries and in Africa in particular. It will therefore be of interest to students, educators, researchers and policy makers in the fields of medicine, agriculture, food science and technology, trade and economics. Food regulatory officers also have quite a lot to learn from the book. Although a lot of the generated data in the area of mycotoxicology are available to the developed world, information on the subject area from Africa is scanty and not usually available in a comprehensive form. This book attempts to address the gap. Being an open access book, it will be of great benefit to scientists in developing countries who have limited access to information due to lack of funds to pay or subscribe for high quality journals and data from commercial publishing and database companies.
Bile Acids and Their Receptors
This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis.
10 Years of Ethnopharmacology
The contributions selected for this ebook span the entire ten-year period and we have selected examples which have had a particular impact on the debates in the field. Broadly speaking, they fall into four main areas: - Overarching reviews within ethnopharmacology - Reviews of specific species or other taxa regarding their pharmacology; phytochemistry and local / traditional use - Assessments of the pharmacological evidence for specific active compounds or classes of compounds - Assessments of the safety and potential risks of herbal substances. With these themes, this eBook contributes to the debate about the evidence- base of such practices incorporating both the scientific evidence available and the local / traditional concepts associated with their use.
Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae?
Advances in anti-cancer chemotherapy over recent years have led to improved efficacy in curing or controlling many cancers. Some chemotherapy-related side-effects are well recognized and include: nausea, vomiting, bone marrow suppression, peripheral neuropathy, cardiac and skeletal muscle dysfunction and renal impairment. However, it is becoming clearer that some chemotherapy-related adverse effects may persist even in long term cancer survivors. Problems such as cognitive, cardiovascular and gastrointestinal dysfunction, and neuropathy may lead to substantial long term morbidity. Despite improvements in treatments to counteract acute chemotherapy-induced adverse effects, they are often incompletely effective. Furthermore, counter-measures for some acute side-effects and many potential longer term sequelae of anti-cancer chemotherapy have not been developed. Thus, new insights into prevalence and mechanisms of cancer chemotherapy-related side effects are needed and new approaches to improving tolerance and reduce sequelae of cancer chemotherapy are urgently needed. The present Research Topic focuses on adverse effects and sequelae of chemotherapy and strategies to counteract them.
Medicinal Plants in Tropical West Africa
First published in 1986, this book describes the most important medicinal plants in tropical West Africa and similar humid tropical climates. After a short introduction about early traditional medicine, the bulk of the book gives an account of locally occurring plants, grouped by their medicinal actions. Plants that affect the cardiovascular and nervous systems are discussed, as are those with antibiotic, insecticidal and molluscicidal properties. Those which affect the hormonal systems of humans are catalogued and so are others that act as adrenal-cortex, sex and thyroid hormones. There is a full botanical index, which includes the commonly found synonyms for many of the plants and the work is illustrated by the author's own water colours. It may be of particular interest and use to pharmacists, biochemists, botanists and pharmacologists and of great value to those who exploit locally available resources in treating diseases in tropical areas.
The Globe Artichoke Genome
This book presents the latest information on the genetics and genomics of the globe artichoke. It focuses on the latest findings, tools and strategies employed in genome sequencing, physical map development and QTL analyses, as well as genomic resources. The re-sequencing of four globe artichoke genotypes, representative of the core varietal types in cultivation, as well as the genotype of cultivated cardoon, has recently been completed. Here, the five genomes are reconstructed at the chromosome scale and annotated. Moreover, functional SNP analyses highlight numerous genetic variants, which represent key tools for dissecting the path from sequence variation to phenotype, as well as for designing effective diagnostic markers. The wealth of information provided here offers a valuable asset for scientists, plant breeders and students alike.
Handbook of African Medicinal Plants
With over 50,000 distinct species in sub-Saharan Africa alone, the African continent is endowed with an enormous wealth of plant resources. While more than 25 percent of known species have been used for several centuries in traditional African medicine for the prevention and treatment of diseases, Africa remains a minor player in the global natural
