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Neuroendocrinology of Appetite
This cutting-edge, interdisciplinary volume describes established and state of the art approaches for exploring the pathways that influence and control appetite, including: behavioural, electrophysiological, neuroanatomical, gene knockout and pharmacological techniques. The book presents key peptide and neurotransmitter systems, together with newly emerging concepts of metabolic signalling and hypothalamic inflammation. The impact of early life experience on neuroendocrine appetite circuits is also looked at, including early programming of these circuits by circulating hormones. Finally, new emerging therapeutic approaches to appetite suppression are discussed, including those linked to bari...
Growth Hormone Secretagogues
Growth hormone secretagogues (GHS) administered alone or in combination with growth hormone releasing hexapeptides, are effective probes for the diagnosis of GH deficiency in both children and adults. Current research has developed and tested different GHS compounds that are active by the oral route, and have improved potency and bioavailability, giving rise to exciting therapeutic possibilities. There was an enthusiastic response from experts in this area to the idea of distilling the huge amount of available data into one multi-authored volume. Each contributor has advanced the field of knowledge, and has here emphasized the practical aspects of their work, reviewing the subject in the lig...
Neuropeptide GPCRs in neuroendocrinology
The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic was to assemble a series of review articles and original research papers on neuropeptide GPCRs and their ligands that would illustrate the different facets of the studies currently conducted in this domain.
Trends in Neuroendocrinology
Neuroendocrinology is the discipline that investigates the interplay between the nervous and endocrine systems i.e. the control of endocrine glands by the central and peripheral nervous systems, the action of hormones on nerve cells and the production of hormones by the nervous system. The present Research Topic is a compilation of contributions stemming from the 8th International Congress of Neuroendocrinology (ICN2014) held in Sydney, Australia, that illustrates various facets of current neuroendocrine research.
Nutrition and Fitness
Mens sana in corpore sano (a healthy mind in a healthy body) is a Latin phrase taken from Giovenale (Satire, X, 356) that remains relevant and is supported by today’s data regarding genetics and nutrition, and their contribution to mental health. The purpose of this Special Issue on “Nutrition and Fitness: Mental Health” is to provide an update on the latest evidence regarding the association between nutrition, physical activity (and inactivity) and physical fitness, and the mental health of children, adolescents, and adults. Particularly, papers (reviews and clinical or experimental studies) dealing with the association between nutrition, physical fitness, and mental health both in general and with regard to specific mental disorders, and nutrients and physical activity as agents for prevention, treatment, or augmentation of treatment for mental disorders, will be included.
Brain Disorders in Critical Illness
Brain dysfunction is a major clinical problem in intensive care, with potentially debilitating long-term consequences for post-ICU patients of any age. The resulting extended length of stay in the ICU and post-discharge cognitive dysfunction are now recognized as major healthcare burdens. This comprehensive clinical text provides intensivists and neurologists with a practical review of the pathophysiology of brain dysfunction and a thorough account of the diagnostic and therapeutic options available. Initial sections review the epidemiology, outcomes, relevant behavioral neurology and biological mechanisms of brain dysfunction. Subsequent sections evaluate the available diagnostic options and preventative and therapeutic interventions, with a final section on clinical encephalopathy syndromes encountered in the ICU. Each chapter is rich in illustrations, with an executive summary and a helpful glossary of terms. Brain Disorders in Critical Illness is a seminal reference for all physicians and neuroscientists interested in the care and outcome of severely ill patients.
Neuroscience Letters
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Growth Hormone Secretagogues in Clinical Practice
Recognizing the urgent need for an up-to-date review of new and innovative research on growth hormone (GH) secretagogues, this exclusive work furnishes the state of the art on the mechanisms of action, design, synthesis, evaluation, and clinical applications of GH secretagogues, including orally active and xenobiotic GH-releasing compounds. Beg
Advances in Eating Disorders
Eating disorders (ED) are a group of mental disorders characterized by an altered food intake and the presence of inappropriate behaviors and thoughts about weight and shape. All EDs lead to physical and psychosocial functioning impairments in the patients which, in turn, may contribute to the persistence of the disease. The severity of EDs has been highlighted by their chronicity, medical complications, comorbidity, and high rates of mortality. Therefore, to address this important health issue, the current Special Issue collected 21 articles (i.e., three reviews and 18 research articles) focusing on the most recent and relevant scientific findings regarding advances in ED, such as genetic and epigenetic factors, biomarkers, comorbidity, clinical phenotypes, neurocognition, treatment predictors, and treatment models and therapeutic targets. Altogether, we believe that the articles contained in this Special Issue have largely achieved the initial objective of providing increased knowledge about the pathogenesis, the risk factors, the maintenance factors, and the most appropriate treatments tools for ED.
