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The Guinea Pigs is a chilling fable about dehumanization and alienation representing Vaculik's vision of the menace of Soviet domination in the wake of the 1969 invasion. Written in 1970, it is a sweeping condemnation of totalitarianism, embedded in a rich, imaginative, highly experimental narrative. In the words of the New York Review of Books it is "one of the major works of literature produced in postwar Europe."
The conflict between myth and technology and the impact of totalitarianism is explored in the tale of an elderly schoolteacher who, while looking for a former pupil, is held for questioning by Communist officials in Romania.