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Peptide And Protein Engineering For Biotechnological And Therapeutic Applications
Peptides and proteins are crucial biomolecules in life. The manifold functions they carry out range from molecular recognition and signaling to catalysis and immune response. However, the native systems are limited to a reduced toolbox of chemical functionalities as well as tridimensional structures. Widening these toolboxes could pave the way to engineer peptides and proteins with enhanced properties compared to their native counterparts and/or with structures and functions unprecedented in Nature. Advances in the chemical and biological synthesis of peptides and proteins, in computational tools, in molecular biology and in high-throughput screening methods are making this realm possible.Th...
Supramolecular Metal-Based Entities for Biomedical and Biological Applications
Research in the discovery of metal supramolecular complexes, mainly formed by the self-assembly of inorganic metal compounds with either inorganic or organic molecules via coordination (or organometallic) bonds, is a rapidly developing and newly rising highlight interdisciplinary field. This Reseach Topic is aimed at providing representative examples of supramolecular metal-based entities for different biological and biomedical applications.
Directory of Graduate Research
Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
Peptide, Protein and Enzyme Design
De Novo Enzyme Design, the newest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume includes the design of metal binding maquettes, insertion of non-natural cofactors, Cu metallopeptides, non-covalent interactions in peptide assemblies, peptide binding and bundling, heteronuclear metalloenzymes, florinated peptides, De Novo imaging agents, and protein-protein interaction. - Continues the legacy of this premier serial with quality chapters on de novo enzyme design - Represents the newest volume in the Methods in Enzymology series, providing premier, quality chapters authored by leaders in the field - Ideal reference for those interested in the study of enzyme design that looks at both structure and mechanism
Little Pieces
Four short stories about smashing things and rearranging the pieces and maintaining good friendships, often with fish. Like the characters in the book, one learns to build a private world out of things others have abandoned and quantify wisdom and strength through the accumulation of scars and wounds. It could likely be done with free energy equations and thermodynamic cycles, but here is it done with lots of illustrations and tales of life on the fringe... a testament to the destructiveness inherent to the creative process.
Biomedical Applications of Functionalized Nanomaterials
Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section...
Bioinorganic Chemistry
This book emphasizes current cutting edge research topics in two areas of modern bioinorganic chemistry: the role of metals in cellular systems involving multiple biomacromolecular components and sophisticated new model systems involving peptide- and non-peptide-based ligands.
Journal
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Faculty and Staff Salary Record
Includes data for the Ann Arbor, Dearborn, and Flint campuses.
