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Human Fungal Pathogens
Whereas plant and insect infections are commonly caused by fungi, only a small minority of the vast diversity of fungal species is pathogenic to humans. Despite this, fungal infections cause considerable morbidity and mortality worldwide. This volume is dedicated to the biology, clinical presentation and management of invasive fungal infections. Major pathogenic fungi are introduced by world-leading experts and the basic principles of fungal virulence are reviewed in the light of new results and experimental technologies that offer unprecedented insights into invasive infections caused by Aspergillus, Candida, Cryptococcus, Pneumocystis and Mucorales. In parallel, the clinical presentation of invasive fungal infections and current approaches to their diagnosis and treatment are summarized to provide an overview of human pathogenic fungi, linking pathogen biology to the clinical presentation of disease.
Oxford Textbook of Medical Mycology
The Oxford Textbook of Medical Mycology is a comprehensive reference text which brings together the science and medicine of human fungal disease. Written by a leading group of international authors to bring a global expertise, it is divided into sections that deal with the principles of mycology, the organisms, a systems based approach to management, fungal disease in specific patient groups, diagnosis, and treatment. The detailed clinical chapters take account of recent international guidelines on the management of fungal disease. With chapters covering recent developments in taxonomy, fungal genetics and other 'omics', epidemiology, pathogenesis, and immunology, this textbook is well suite...
Fungal Pathogenesis
Stresses molecular and biochemical studies of opportunistic and frank fungal pathogens! This book gives a comprehensive overview of human pathogenic fungi that offers a current and concise survey of virulence factors, host responses and recognition, treatment and diagnosis of infections, invasive enzymes, intracellular survival, morphogenesis, adaptation, and properties of major fungal pathogens that contribute to disease. Focuses on human fungal infections, including candidiasis, pneumocystosis, aspergillosis, and cryptococcosis. With over 3700 references to accommodate continuing study, Fungal Pathogenesis covers natural and acquired immunity, vaccine development, and immune reconstitution...
Spektrum Kompakt - Pathogene Pilze
Bei gefährlichen Pilzen denken viele wohl zuerst an Fliegenpilz, Knollenblätterpilz und andere Giftpilze. Ein deutlich größeres Risiko geht allerdings von eher unscheinbaren Arten aus, die ständig in unserem Umfeld lauern. Teils sind sie so klein, dass wir sie mit dem bloßen Auge gar nicht sehen. Dennoch können sie uns und andere Lebewesen mitunter todkrank machen; manche raffen sogar ganze Tierpopulationen dahin. Andere sind zwar sichtbar. Doch sobald sie sich zeigen, ist es für er-krankte Organismen meist schon zu spät – dazu zählen etwa solche, die massenhaft Nutzpflanzen vernichten. Diese Spektrum-Kompakt-Ausgabe fasst zusammen, welche tödlichen Bedrohungen im Reich der Pilze lauern.
Computational Systems Biology of Pathogen-Host Interactions
A thorough understanding of pathogenic microorganisms and their interactions with host organisms is crucial to prevent infectious threats due to the fact that Pathogen-Host Interactions (PHIs) have critical roles in initiating and sustaining infections. Therefore, the analysis of infection mechanisms through PHIs is indispensable to identify diagnostic biomarkers and next-generation drug targets and then to develop strategic novel solutions against drug-resistance and for personalized therapy. Traditional approaches are limited in capturing mechanisms of infection since they investigate hosts or pathogens individually. On the other hand, the systems biology approach focuses on the whole PHI ...
The Patient Room
The patient room is the smallest cell of the hospital organism. Its layout determines the structure of the ward and is therefore a decisive factor for the entire building. Many requirements have to be met. The patient's sense of well-being can be positively influenced by the design: homely materials, an attractive view and sufficient privacy are important objectives. Equally important are the working conditions for the staff, especially short distances and an efficient care routine. Finally, even the risk of infection can be reduced by a conscientiously planned room layout. This publication provides a systematic overview of the design task patient room and shows exemplary solutions: both typologically and in selected case studies.
Systems Biology of Microbial Infection
The systems biology of microbial infections aims at describing and analysing the confrontation of the host with bacterial and fungal pathogens. It intends to understand and to model the interaction of the host, in particular the immune system of humans or animals, with components of pathogens. This comprises experimental studies that provide spatio-temporal data from monitoring the response of host and pathogenic cells to perturbations or when interacting with each other, as well as the integrative analysis of genome-wide data from both the host and the pathogen. In perspective, the host-pathogen interaction should be described by a combination of spatio-temporal models with interacting mole...
Biodeterioration of Cultural Heritage
Fungi-induced stains on paper are one of the most challenging forms of biodeterioration to study and to prevent; this is because they involve living organisms, and the ways in which fungi respond to changes in the environment and modifications of paper are unpredictable. Yet, there is a great desire among those who encounter fungi on documents, manuscripts, or artwork to remove fungi and clean the paper. This experience in most cases is particularly challenging. What are the reasons behind this challenge? This ground-breaking book attempts to answer this question, among others, by exploring the complex interfacial forces between paper, fungi, and their pigmented secretions which result in bi...
Handbook of Meningococcal Disease
A comprehensive overview of recent advances, from current basic research and epidemiology, to novel therapeutic strategies and clinical management. Here, the leading scientists who have made major advances in the field provide up-to-date reviews and describe their current knowledge and concepts. As such, this is the first volume to summarize the implications of the meningococcus genome-sequencing project, emphasizing the novel strategies in vaccine development. Following a look at the history, the authors go on to treat the epidemiology of meningococcal disease, as well as the genetics, structure and function of virulence factors. Further chapters cover cross-talk between meningococci and host cells, genomics and immunobiology. The result is a standard handbook for all scientists working in the field. While aimed at advanced specialists in basic research, epidemiologists, public health workers, vaccine developers and clinicians, the book is equally appropriate as introductory reading for graduates embarking on their career in this field.
