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In recent years, the understanding of the pathophysiological processes of atherosclerosis, a chronic inflammatory disease of the vessel wall being the leading cause for mortality in industrial countries, has tremendously increased. The feasibility of translating such knowledge to novel therapeutic approaches is currently being explored at various levels. This book highlights advances in atherosclerosis and links these to relevant therapeutic strategies. It compiles and details cutting-edge research in cardiovascular medicine from internationally renowned authors.
The American Heart Association’s Scientific Sessions 2019 is bringing big science, big technology, and big networking opportunities to Philadelphia, Pennsylvania this November. This event features five days of the best in science and cardiovascular clinical practice covering all aspects of basic, clinical, population and translational content.
In this eBook, we have grouped together 16 original contributions which have addressed the translational potential for therapeutics developed on the conceptual framework of the resolution of inflammation. The take home message of our effort, and the efforts of our colleagues who wrote these pieces, is that completely different drugs can be designed and modelled on the mediators and targets of resolution. By implementing this 180° shift in the way we plan the drug development programme (that is by focusing on agonists and/or promoting the actions of pro-resolution agonists) we can offer a fresh approach to the clinical management of chronic diseases that affect the modern society. With this ...
Increasing evidence suggests that hidden, low-level inflammation may be the number one cause of modern disease. Shilpa Ravella, an expert in nutrition and the gut, explains why our immune systems are turning against us and what we might do about it. 'Controlling inflammation is the key to good health and this beautifully written and researched book is the best way to understand it' TIM SPECTOR, #1 bestselling author of Food for Life 'A beautiful and authoritative dive into one of the most important scientific frontiers of our time' DANIEL M. DAVIS, Professor of Immunology and author of The Beautiful Cure ___ Inflammation is the body's response to injury and foreign microbes. But as our envir...
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Comprehensive and in-depth in its coverage, Atherosclerosis: Cellular, Molecular & Biochemical Mechanism and Novel Therapy reviews the recent progress in atherosclerosis research and offers cutting edge perspectives from experts in the field. Written by an international team of authors including leading physician-scientists, research experts and physicians, chapters are divided into four major sections, covering risk factors, cellular and molecular mechanisms, biochemical mechanisms and novel and future therapeutics. Atherosclerosis: Cellular, Molecular & Biochemical Mechanism and Novel Therapy analyses recent progress from both conceptual and technological perspectives, suggesting new directions for atherosclerosis research and treatment for a growing population of researchers and clinicians in cardiovascular and related fields.
This is the secret to living a longer, wiser and happier life; the key to a smarter, more productive, healthier you. Welcome to the power of the Downstate. In The Power of the Downstate, Sara C. Mednick PhD will show you how to achieve robust health, sustained productivity and brilliant thinking by maintaining balance and finding harmony with your natural rhythms. The Downstate is the time and space in which restoration and recuperation from the day-to-day stress of living take place. It's when our body can restore our most vital functions at a cellular level, including giving our heart, brain and metabolism a rest. In essence, it's our opportunity to plug ourselves into a metaphorical outle...
This volume reviews available mouse models of atherosclerosis, basic aspects of disease initiation and progression, and the visualization of atherosclerotic lesions with invasive and non-invasive techniques that are widely used both in basic research and in the clinic. The chapters catalogue a wide range of in vitro and in vivo experimental methods used for atherosclerosis research, including thorough protocols and valuable notes based on the authors’ personal wet lab experience. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Methods in Mouse Atherosclerosis will be a valuable working guide for researchers performing mouse-based atherosclerosis studies.