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Pharmacophore Perception, Development, and Use in Drug Design
In the early 1900s, Paul Ehrlich first defined pharmacophores as molecule frameworks that carry the essential features responsible for a drug's biological activity, and the modern definition is little changed. The 27 studies here begin by tracing the evolution of the concept in pharmaceutical research, then cover analog-based and receptor-based varieties, new algorithms, and the future of research. Among the specific topics: pharmacophores based on multiple common-feature alignments; modeling programs including HypoGen, DISCO, Catalyst, HipHop, GASP, Chem-X, Apex-3D, CoMFA; pharmacophore-based molecular docking, a technique for developing a pharmacophore model that accommodates inherent protein flexibility; and the effect of variable weights and tolerances on predictive model generation. Books in Print lists only one other book on the topic of pharmacophores. Annotation copyrighted by Book News, Inc., Portland, OR
Religion and Poverty
Nowadays religions are especially important for those who are living in countries of the formerly so-called 'Third World'. The miseries of life seem to be so hard that just an afterlife in a transcendent paradise is promising relief. Consequently, there seems to be a close connection between religion and poverty, especially in the 21st century, when the hope for a better afterlife has become a driving force of the poor population of the world. However, what could be interpreted as a proof of the Marxist doctrine of religion as opium of the people, for sure deserves a more multiperspectival approach, which would not just cover the recent years of human history, but past centuries as well as the different religions around the globe. Therefore the second issue of Global Humanities traces the interrelationship between religion and poverty not only from a historical, but also from a sociological, religious and artistic perspective.
Computational Medicinal Chemistry for Drug Discovery
Observing computational chemistry's proven value to the introduction of new medicines, this reference offers the techniques most frequently utilized by industry and academia for ligand design. Featuring contributions from more than fifty pre-eminent scientists, Computational Medicinal Chemistry for Drug Discovery surveys molecular structure computation, intermolecular behavior, ligand-receptor interaction, and modeling responding to market demands in its selection and authoritative treatment of topics. The book examines molecular mechanics, semi-empirical methods, wave function-based quantum chemistry, density functional theory, 3-D structure generation, and hybrid methods.
On the Path of the Prophet
Fethullah Gülen, a contemporary scholar of Islam and activist with a large worldwide following, has spent his entire life studying and teaching the Sunnah, the tradition of the Prophet Muhammad, pbuh. This book explores his holistic approach to the vast knowledge of hadith and how he puts his focus on practical interpretations of the Sunnah. Dr. Erdil shows, through the example of Gulen, that it is possible to provide solutions to the problems at the individual, familial and social levels today if the way of the Prophet is studied in detail and interpreted within the context of the current era.
The Liberalisation of the Islamists in Turkey During 1990’s: The Debates Around the Medina Document and Civil Society Project
Dr. Unal Giindoan The Liberalisation of the Islamists in Turkey During 1990's: The Debates Around the Medina Document and Civil Society Project This book takes snapshots from the venture of the Islamic Movement during second half of the 1990's in Turkey. It was the Civil Society Project, as proposed by Ali Bulac a prominent intellectual, which claimed to establish philosophical basis for a political and social restructuring of Turkey depending upon the basic premises of the Medina Document, which was signed among Muslims, Jews and Pagans of Medina City just after the Prophet Muhammed's migration in 622. The Project was a break from the tradi-tional understanding of Islamic politics both in Turkey and in the Muslim world. It was because of its focus on pluralism, multi-culturalism, democracy, human rights and many other liberal assumptions. This was a turning point in Turkish politics since the discussions created a liberal atmosphere among Islamist, leftist and rightists which at the end resulted in the mass acceptance of Islamic political parties by the voters since midst 1990's. The rise of first Refah Party and then AK Party owe much to this new understanding.
