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Alcohol, Tobacco and Cancer
The first part of this book addresses in detail the correlations between alcohol and carcinogenicity, focusing on specific organs such as the upper aerodigestive tract, liver, colon, pancreas and breast. This includes the impairment of methionine-folate metabolism and DNA methylation by alcohol, as well as the use of s-adenosylmethionine to prevent cancer. Furthermore, the synergistic effects of reactive oxygen species and iron in producing liver cancer are addressed. The second part is dedicated to the role of tobacco in lung and digestive tract cancers and to their prevention, highlighting the role of phytochemicals. More specifically, the mutagenic, mitogenic, precarcinogenic, anti-apoptotic, and immunosuppressive properties of nicotine which are involved in the development of cancer, and the possible use of nicotine vaccine in the prevention of mortality associated with tobacco, are discussed.
Nanoethics and Nanotoxicology
Nanobiotechnology is a fast developing field of research and application in many domains such as in medicine, pharmacy, cosmetics and agro-industry. The book addresses the lastest fundamental results on nanotoxicology and nanoethics, and the enormous range of potential applications in the fields of medical diagnostics, nanomedicine, and food and water administration. Nanoscale objects have properties leading to specific kinds of behaviour, sometimes exacerbating their chemical reactivity, physical behaviour, or potential to penetrate deeply within living organisms. Hence it is important to ensure the responsible and safe development of nanomaterials and nanotechnologies. This fourth volume in the Nanoscience series should make its mark, by presenting the state of the art in the fields of nanotoxicology and nanoethics. This is the first book to combine both scientific knowledge and ethical and social recommendations. It also presents specific policies on nanotechnologies set up by national and international authorities. This book is of interest to engineers, researchers, and graduate students.
Mesothelioma
Mesothelioma used to be a rare disease, but because of the widespread use of asbestos it has now been described as an epidemic around the world. The disease has proven exceptionally resistant to common forms of treatment (chemotherapy, radiotherapy and surgery). Mesothelioma has a very aggressive natural history with a median survival of around 9 m
Squamous Cell Head and Neck Cancer
Leading expert physicians and investigators from around the world review the state-of-the-art in the management of squamous cell head and neck cancer, with emphasis on coordinating different treatment modalities. The authors address several surgical issues, including laser-based surgery, larynx preservation approaches, salvage surgery, and neck management after non-operative treatment. They also discuss definitive radiation for larynx cancer, brachytherapy, altered fractionation radiation, intensity modulated radiation therapy, and the importance of tumor hypoxia, as well as the role of chemotherapy in sequential, concurrent, and adjuvant multi-modality treatment schedules. Other topics of special interest include targeted and gene therapies, multimodality management of nasopharyngeal cancer, chemoprevention, toxicity modification, quality of life outcomes, symptom palliation, and epidemiology.
American Journal of Numismatics and Bulletin of the American Numismatic and Archaeological Society
Vols. 42-49 include the Proceedings of the American numismatics society, 1908-1915/16.
Head and Neck Cancer
Exciting advances are occurring in the understanding of the molecular pathogenesis of squamous head and neck cancers. Epidemiology, staging and screening, as well as premalignancy, chemoprevention and the molecular biology of head and neck cancer, lay the groundwork for the understanding of the clinical chapters that follow. Controversial treatments will be compared to the standard management of patient care. Therapy chapters are divided into stage or category specific (resectable advanced, unresectable advanced or metastatic) problems, allowing the reader to review the current standards and options for patient types or specific patients easily. Considerations of supportive care, late toxicities and quality of life, often overlooked are reviewed in detail. This is a comprehensive summary of the current state of the art research and treatment.
Prions and Diseases
Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.
