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This primer describes the range of NMR techniques commonly used in modern research, and explains how these experiments actually work, giving a unique perspective on this powerful experimental tool.
Nuclear Magnetic Resonance Spectroscopy is the only "tool" available for the determination of high-resolution biological molecule structure in solution. This volume includes methods for expeditiously analyzing the vast amount of data produced by the new 3D and 4D NMR techniques and for generating structures from the data and for assessing the quality of those structures. Application to various classes of important proteins and protein-ligand complexes illustrate uses of the methodology presented. Examination of techniques to explore the dynamic nature of proteins complete the volume.
Nuclear Magnetic Resonance offers an accessible introduction to the physical principles of liquid-state NMR, with examples, applications, and exercises provided throughout to enable beginning undergraduates to get to grips with this important analytical technique.
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Nobody can know everything. For the successful application of techniques based on nuclear magnetic resonance to clinical problems, it is a vital necessity that individuals with widely different skills should learn a little of each others' trades by co-operation and communication. Ernest Cady has long proved himself a master of these arts to his colleagues at University College London, and by writing this excellent book he extends his experience to a wide circle of readers. Although the nuclear magnetic resonance (NMR) phenomenon had been predicted theoretically (and to some degree demonstrated experimentally) appreciably earlier, it required the advances in electronics that took place during World War II to turn NMR into a practical technique, as demonstrated independently in 1946 by Bloch and Purcell. Since then, NMR has been used extensively and increasingly by chemists and physicists. In the 1970s the first applications of NMR to animal organs yielded important advances in our knowledge of the biochemical and physiological processes as they occur in genuinely intact tissues. They showed incidentally that some conventional techniques introduce significant artifacts.
Nuclear magnetic resonance (NMR) is an enormously powerful and versatile method for investigating the structure and dynamics of molecules. This book provides the conceptual and theoretical tools needed to understand the inner workings of modern NMR experiments. The approach is relatively informal, accessible and concise.
Introduction : dispossession in focus : between ancestral ties and settler territoriality -- Six geobiographies : senses of site in the white settler world -- Space and the settler geographical imagination : the survey, the camera, and the problematic of waste -- A clock for seeing : revelation and rupture in settler colonial landscapes -- Tanga Whaka-ahua or, the man who makes the likenesses : managing indigenous presence in colonial landscapes -- Colonial encounter, epochal time, and settler romanticism in the nineteenth century -- Noble cities from primeval rorest : settler territoriality on the world stage -- Settler nativity : nations and natures into the twentieth century -- Conclusion : settler colonialism, reconciliation, and the problems of place.
Every Shabbat Jacob and his horse Soosie set out to deliver Ezra and Esther's delicious challahs to their Jerusalem neighbors. But what happens when Jacob is sick? Will everyone get their challah in time for Shabbat? This heart-warming story is based on the history of Angel Bakery, the oldest commercial bakery in Israel. Charming illustrations capture picturesque turn of the century Jerusalem and its eclectic group of residents.
In 2014 the UK government launched an investigation into the "Trojan Horse" affair, an alleged plot to "Islamify" several state schools in Birmingham. In this book, John Holmwood, who was an expert witness in the professional misconduct cases brought against the teachers in the school, and Therese O'Toole, who researches the government's counter-extremism agenda, challenge the accepted narrative, arguing that a major injustice was inflicted on the teachers, and they go on to show how the affair was used to criticize multiculturalism and justify the expansion of a broad and intrusive counter-extremism agenda.