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Antiviral Drugs and Interferon: The Molecular Basis of Their Activity
Research on antiviral drugs and their mode of action in infected cells. in animals and in man. has led to a better understanding of the molecular pro cesses involved in virus replication. Screeninq of large numbers of natural and semisynthetic compounds resulted in the characterization of certain sub stances that had a limited efficiency as antiviral druqs. A few chemically synthesized compounds were also found to be effective as antiviral agents in the chemotherapy of human virus diseases. A major difficulty in the develop ment of effective antiviral agents has been the lack of selectivity. and toxicity for uninfected cells. of drugs that effectively inhibited virus replication in vitro. Fu...
Targets for the Design of Antiviral Agents
This pUblication contains the Review Lectures presented at a joint NATO Advanced Study Institute and FEES Advanced Study Course held at Les Arcs, Bourg-8aint-Maurice, France, from the 19th June - 2nd July 1983. The Course, entitled "Targets for the Design of Antiviral Agents" was in some ways a sequel to the NATO-FEES Course held at SOGESTA (near Urbino), Italy from the 7th - 18th May 1979 and published as volume A26 in this series. During the subsequent four years, we have witnessed the first of the "new generation" of antiviral compounds, which are more efficacious and less toxic than the "classical" antiviral drugs, reach the clinic and we felt that it w~s the right time to assess the fut...
Hitler's Shadow
This report is based on findings from newly-declassified decades-old Army and CIA records released under the Nazi War Crimes Disclosure Act of 1998. These records were processed and reviewed by the National Archives-led Nazi War Crimes and Japanese Imperial Government Records Interagency Working Group. The report highlights materials opened under the Act, in addition to records that were previously opened but had not been mined by historians and researchers, including records from the Office of Strategic Services (a CIA predecessor), dossiers of the Army Staff's Intelligence Records of the Investigative Records Repository, State Dept. records, and files of the Navy Judge Advocate General. This is a print on demand report.
Static Analysis
This book constitutes the refereed proceedings of the 9th International Static Analysis Symposium, SAS 2002, held in Madrid, Spain in September 2002. The 32 revised full papers presented were carefully reviewed and selected from 86 submissions. The papers are organized in topical sections on theory, data structure analysis, type inference, analysis of numerical problems, implementation, data flow analysis, compiler optimizations, security analyses, abstract model checking, semantics and abstract verification, and termination analysis.
Handbook of Prompt Gamma Activation Analysis
Prompt gamma activation analysis (PGAA) is a unique, non-destructive nuclear analytical method with multi-element capabilities. It is most effective if intense neutron beams (especially cold beams) of nuclear reactors are used to induce the prompt gamma radiation. Based largely on the authors' pioneering research in cold neutron PGAA, the handbook describes the methodology in self-contained manner and reviews recent applications. The library of prompt gamma ray data and spectra for all natural elements is a unique aid to the practitioner. The level is understandable by a broad audience, which facilitates teaching and training. The Handbook of Prompt Gamma Activation Analysis is a comprehensive handbook written for those practising the method, wanting to implement it at a reactor facility, or just looking for a powerful non-destructive method of element analysis. The book is also useful for nuclear physics, chemistry and engineering scientists, scholars and graduate students interested in neutron-induced gamma ray spectroscopy and nuclear analytical methods.
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The Securitisation of Climate Change and the Governmentalisation of Security
This book provides an in-depth analysis of the securitisation of climate change in the US, Germany and Mexico and offers a rethinking of securitisation theory. Resting on a Foucauldian governmentality approach, it discusses how different climate security discourses have transformed the political handling of climate change and affected policies, practices and institutions. Going beyond the literature’s predominant focus on the global level, it gives a fine-grained examination of the political and institutional changes in different national contexts. Drawing on the governmentalisation of security, the book develops a new understanding of securitisation that focuses on the role of power. In d...
Current Catalog
First multi-year cumulation covers six years: 1965-70.
