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The Cleveland Orchestra Story
How did a late-blooming midwestern orchestra rise amid gritty Big Industry to become a titan in the world of Big Art? This groundbreaking book tells the complete story of the people and events that shaped the Cleveland Orchestra into a classical music legend. It taps the most authoritative sources to show how decisions were made along the often bumpy road to artistic and financial success. Told with plenty of anecdotes and intriguing behind-the-scenes details.
The International Legal Régime for the Protection of the Stratospheric Ozone Layer
The first edition of Professor Yoshida's monograph, The International Legal Régime for the Protection of the Stratosphere Ozone Layer, has been the most comprehensive contemporary study of the international ozone régime. In the second revised edition, he analyses important developments of the ozone treaty régime.
Understanding Toscanini
As America's symbol of Great Music, Arturo Toscanini and the "masterpieces" he served were regarded with religious awe. As a celebrity personality, he was heralded for everything from his unwavering stance against Hitler and Mussolini and his cataclysmic tantrums, to his "democratic" penchants for television wrestling and soup for dinner. During his years with the Metropolitan Opera (1908-15) and the New York Philharmonic (1926-36) he was regularly proclaimed the "world's greatest conductor ." And with the NBC Symphony (1937-54), created for him by RCA's David Sarnoff, he became the beneficiary of a voracious multimedia promotional apparatus that spread Toscanini madness nationwide. Accordin...
Thrombin
Research on thrombin structure and function has progressed significantly over the past three decades. We are continually discovering new functions f()r this enzyme in biology. Yet, until quite recently, a full, detailed, three dimensional picture of its structure was difficult to attain. We believe that this text represents a turning point and, more appropriately, a new start ing point for thrombin studies. Our goal for this text is to present a thorough and rounded-out coverage of thrombin chemistry and biochem istry in order to provide the biochemist and physiologist with an excellent desk reference on almost any thrombin-related problem. This volume is organized into three general thrombi...
Probabilistic Graphical Models
This book constitutes the refereed proceedings of the 7th International Workshop on Probabilistic Graphical Models, PGM 2014, held in Utrecht, The Netherlands, in September 2014. The 38 revised full papers presented in this book were carefully reviewed and selected from 44 submissions. The papers cover all aspects of graphical models for probabilistic reasoning, decision making, and learning.
Cries of the Sea
A treasure lies at the bottom of the oceans. This treasure takes the form of a legal and ethical principle which may illuminate the potential for an enriching international community in a world of growing disparities. It is the principle of the Common Heritage of Humanity. The 1982 United Nations Convention on Law of the Sea delineated an Area and then proclaimed the Area and its resources `the common heritage of mankind'. The author suggests that the terms `common', `heritage', and `humanity' invite a larger perspective on the law underlying the Convention. Cries of the Sea provides a unique view of `the deep blue sea' through the lens of the politics of international ocean law and policy a...
Integration of Pharmaceutical Discovery and Development
In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and m...
Ozone Diplomacy
Hailed in the Foreign Service Journal as a landmark book that should command the attention of every serious student of American diplomacy, international environmental issues, or the art of negotiation, and cited in Nature for its worthwhile insights on the harnessing of science and diplomacy, the first edition of Ozone Diplomacy offered an insider's view of the politics, economics, science, and diplomacy involved in creating the precedent-setting treaty to protect the Earth: the 1987 Montreal Protocol on Substances That Deplete the Ozone Layer. The first edition ended with a discussion of the revisions to the protocol in 1990 and offered lessons for global diplomacy regarding the then just-m...
Promoting Compliance in an Evolving Climate Regime
Assesses the existing compliance system of the UN climate regime and examines the key challenges for the emerging post-2012 system.
