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In the late eighteenth century, the Upper Valley of Virginia experienced a conflict between the elitist culture of the gentry and the more republican values of the populace. Albert Tillson addresses here several major issues in historical scholarship on Virginia and the southern backcountry, focusing on changing political values in the late colonial and Revolutionary eras. In the colonial period, Tillson shows, the Upper Valley's deferential culture was much less pervasive than has often been suggested. Although the gentry maintained elitist values in the county courts and some other political arenas, much of the populace rejected their leadership, especially in the militia and other defense...
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Current Topics in Cellular Regulation: Volume 30 is a collection of papers that deals with eukaryotic DNA methylation, gene expression, regulation of nitrogenase activity, and the recognition of DNA by Type II restriction enzymes. Other papers discuss the mitochondrial Krebs cycle, enzyme mechanisms, transducin, and calcium-dependent cellular processes. One paper explains that methylation and demethylation of the DNA are complicated active processes, involving many aspects of the genome. The paper also notes that within the gross changes in methylation patterns, specific CpG sites play important roles in the expression or shutdown of target genes. Another paper concludes that, mono-ADP ribos...