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Dementia in Clinical Practice
This publication summarizes the most recent advances in neurobiology, diagnostic approaches and therapeutics of the major dementing illnesses such as Alzheimer's disease, frontotemporal dementia, Lewy body disease, and vascular dementia. In a succinct, practical and comprehensive manner, it provides an updated view of the disorders likely to be encountered in a daily practice. Each section is focused on a major form of dementia and is organized following the same scheme reviewing the pathophysiology of the disease, its diagnostic challenges, its characteristic neuroimaging features, therapeutic interventions and patient management issues. Avoiding an overspecialized approach, the book bridges the gap between clinical practice, advanced imaging, recent therapeutics and basic sciences. Thus, it serves as an excellent guide for mental health professionals working in the field of dementia as well as primary care physicians and students.
Management of Aging
One of the world's major geriatric departments is housed in the Geneva University Hospital and has a 36-year-old history behind it. Some of its developments are set out in this book. Care programs such as geriatric concepts of care, community based support, convalescent beds, memory clinics, palliative medicine and care and practice of clinical ethics are discussed. Research has focussed on 15 years of comparative cross-sectional studies on aging in an urban and a rural area of Switzerland, prevalence of dementia in Geneva and Zurich, clinico-neuropathological correlation, fall prevention, hip fracture outcomes and the impact of nutrition on the recovery of hip fractures. Teaching activities...
Bioinformatics and Computational Biology
Bioinformatics and Computational Biology: Technological Advancements, Applications and Opportunities is an invaluable resource for general and applied researchers who analyze biological data that is generated, at an unprecedented rate, at the global level. After careful evaluation of the requirements for current trends in bioinformatics and computational biology, it is anticipated that the book will provide an insightful resource to the academic and scientific community. Through a myriad of computational resources, algorithms, and methods, it equips readers with the confidence to both analyze biological data and estimate predictions. The book offers comprehensive coverage of the most essenti...
Neuroscientific Research for Management of Dementia
The articles in this eBook are divided into three main chapters. Chapter 1 focuses on the role of specific proteins in the pathological processes of neurodegeneration, specifically Alzheimer's disease. Chapter 2 describes novel candidates and risk factors for the diagnosis of Alzheimer's disease. Chapter 3 targets various therapeutic interventions from pharmacological targets to cognitive function. This eBook thus provides an overall overview of the latest research in understanding mechanisms leading to the development of Alzheimer's disease, diagnosis, and therapeutic interventions.
Learning and Memory
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The Clinical Management of Early Alzheimer's Disease
The enormous human and economic toll of Alzheimer's Disease in societies in which more and more people are living into old age is well-recognized. Scientists and practitioners alike have been working to limit it. Their major focus has been patients in the later stages of the disease, when dementia is fully established. Yet patients in the early stages of cognitive decline, far more numerous, often still living independently with family members, present a bewildering variety of challenges. Bringing together leading authors with diverse expertise, this Handbook offers the first comprehensive overview of approaches to the management of early-stage issues. The authors summarize the important imp...
The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration
Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Neverth...
