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Otorhinolaryngology- Head & Neck Surgery
Otorhinolaryngology- Head & Neck Surgery is the latest edition of this comprehensive two-volume guide to all the sub-specialties of otorhinolaryngology, including brand new chapters and the most recent developments in the field. New topics in this edition include laryngopharyngeal reflux, trauma and stenosis of the larynx, and laryngeal cancer, bringing the text firmly up to date. Illustrated in full colour across 2000 pages, this vast two-volume set is an ideal source of reference for otorhinolaryngoloy practitioners and residents.
Immunotherapy for Head and Neck Cancer
This book is a comprehensive summary of the literature on the scientific rationale and clinical development of immunotherapy for head and neck cancers. Head and neck cancer is a biologically diverse group of cancers that bear a common hallmark - evasion of host immune surveillance through innate or acquired mechanisms. The etiological association between the Human Papilloma virus (HPV) and some squamous head and neck cancers, the Epstein-Barr virus (EBV) and nasopharyngeal cancer has provided further impetus for evaluating immunotherapy in this group of cancers. The successful development of anti-programmed cell death protein-1 (PD-1)/ ligand (PD-L1) and CTLA-4 antibodies in solid tumours ha...
Critical Issues in Head and Neck Oncology
This is an open access book. With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up. All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.
A Companion to Late Medieval and Early Modern Milan
Milan was for centuries the most important center of economic, ecclesiastical and political power in Lombardy. As the State of Milan it extended in the Renaissance over a large part of northern and central Italy and numbered over thirty cities with their territories. A Companion to Late Medieval and early Modern Milan examines the story of the city and State from the establishment of the duchy under the Viscontis in 1395 through to the 150 years of Spanish rule and down to its final absorption into Austrian Lombardy in 1704. It opens up to a wide readership a well-documented synthesis which is both fully informative and reflects current debate. 20 chapters by qualified and distinguished scho...
Advances in Radiotherapy for Head and Neck Cancer
Modern Radiotherapy (RT) plays a key role in the management of Head and Neck Cancer (HNC). More precise delivery techniques, advanced image-guidance, and adaptive treatments characterize modern RT, enabling safer treatments with enhanced therapeutic window. Although patients identify the cure as their most important treatment outcome, complications related to treatment are a recognized problem as follow-up increases among those cured within this oncologic setting. This is particularly relevant for HPV-related oropharyngeal cancer (OPSCC), as these patients are younger, healthier, and more reactive to treatment. Thus, given the longer life expectancy, the jeopardizing impact of side effects on quality of life (QoL) and psychosocial functioning represent a forefront topic for HNC Researchers. De-escalation protocols have been developed recently, and, although not definitive, evidence is growing. This pertains particularly, but not exclusively, to HPV-related OPSCC.
Neuroendocrine Neoplasia Management
This book provides the most recent update on the management of neuroendocrine neoplasia (NEN), a term covering all tumors of various organs and/or with a particular histology, including MEN (multiple endocrine neoplasia) related tumors, MiNEN (mixed neuroendocrine-non-neuroendocrine neoplasms), NEC (neuroendocrine carcinoma) and Merkel’s carcinoma. NENs are heterogeneous in their biology, clinical presentation and prognosis, showing a great variability in aggressiveness and therapy response. As a result, their treatment is based on a large spectrum of options. The standard therapies are surgery in early disease, various loco-regional procedures in certain conditions and mostly of a palliat...
