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Modelling Methodology for Physiology and Medicine
Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that un...
Anselm of Havelberg: Deeds into Words in the Twelfth Century
Important for the political and literary history of the Middle Ages, Anselm served St. Norbert of Xanten, advised three German rulers, acted as a papal legate, and held the offices of bishop of Havelberg and archbishop of Ravenna. He is most famous for his written account of theological debates he held with a Greek archbishop and for his History of the Faithful. Lees's book is the first comprehensive study of Anselm's life and writings, drawing the two together in a new interpretation of the History, the Debates, and Anselm's blistering attack on the monastic life, as well. It will be of great value to those interested in medieval political, intellectual or church history, as well as those interested in the literature of the twelfth century.
Medieval Italy
Medieval Italy gathers together an unparalleled selection of newly translated primary sources from the central and later Middle Ages, a period during which Italy was famous for its diverse cultural landscape of urban towers and fortified castles, the spirituality of Saints Francis and Clare, and the vernacular poetry of Dante, Petrarch, and Boccaccio. The texts highlight the continuities with the medieval Latin West while simultaneously emphasizing the ways in which Italy was exceptional, particularly for its cities that drove Mediterranean trade, its new communal forms of government, the impact of the papacy's temporal claims on the central peninsula, and the richly textured religious life ...
The Bishop's Palace
This lavishly illustrated book looks at the art and architecture of episcopal palaces as expressions of power and ideology. Tracing the history of the bishop's residence in the urban centers of northern Italy over the Middle Ages, Maureen C. Miller asks why this once rudimentary and highly fortified structure called a domus became a complex and elegant "palace" (palatium) by the late twelfth century. Miller argues that the change reflects both the emergence of a distinct clerical culture and the attempts of bishops to maintain authority in public life. She relates both to the Gregorian reform movement, which set new standards for clerical deportment and at the same time undercut episcopal cl...
AACR 2017 Proceedings: Abstracts 1-3062
The AACR Annual Meeting highlights the best cancer science and medicine from institutions all over the world. Attendees are invited to stretch their boundaries, form collaborations, attend sessions outside their own areas of expertise, and learn how to apply exciting new concepts, tools, and techniques to their own research. Part A contains abstracts 1-3062 accepted for the 2017 meeting.
The Battle of Crécy
This casebook is the most extensive collection of documents ever assembled for the study of one of the famous battles in history — the Battle of Crécy (1346).
John Hawkwood
Winner, 2008 Otto Gründler Book Prize, The Medieval Institute Winner, 2008 Otto Gründler Book Prize, The Medieval Institute Notorious for his cleverness and daring, John Hawkwood was the most feared mercenary in early Renaissance Italy. Born in England, Hawkwood began his career in France during the Hundred Years' War and crossed into Italy with the famed White Company in 1361. From that time until his death in 1394, Hawkwood fought throughout the peninsula as a captain of armies in times of war and as a commander of marauding bands during times of peace. He achieved international fame, and city-states constantly tried to outbid each other for his services, for which he received money, lan...
Pharmacokinetics in Drug Development
In this volume, the specific challenges and problems facing the evaluation of new oncology agents are explored with regards to pharmacokinetic, pharmacodynamic modeling and clinical pharmacology development strategies. This book delivers, with an emphasis on the oncology therapeutic area, the goals set in the first three volumes: namely – to provide clinical pharmacologists practical insights for the application of pharmacology, pharmacokinetics and pharmacodynamics for new drug development strategies. Pharmacokinetic-pharmacodynamic concepts for tyrosine kinases, the evaluation of cardiac repolarization prolongation through QTc interval effects, efficacy- and safety-response analyses to support new drug approvals, clinical and preclinical tumor growth modeling, and flat- vs weight-based dose selection are showcased from an oncology clinical pharmacologist’s point-of-view. Oncology development strategies are surveyed for new FDA-approvals to identify patterns in expectations at time of first approval. The special considerations necessary to address combination drug development, metronomics, biosimilars and breakthrough therapies are also presented.
Lust for Liberty
Lust for Liberty challenges long-standing views of popular medieval revolts. Comparing rebellions in northern and southern Europe over two centuries, Samuel Cohn analyzes their causes and forms, their leadership, the role of women, and the suppression or success of these revolts. Popular revolts were remarkably common--not the last resort of desperate people. Leaders were largely workers, artisans, and peasants. Over 90 percent of the uprisings pitted ordinary people against the state and were fought over political rights--regarding citizenship, governmental offices, the barriers of ancient hierarchies--rather than rents, food prices, or working conditions. After the Black Death, the connect...
