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Management of Treatment-Resistant Major Psychiatric Disorders
A sizable percentage of patients with major psychiatric disorders do not respond to the first or second treatments they receive. This book summarizes the latest evidence from clinical studies concerning the treatment of patients with treatment-resistant psychiatric disorders. Both pharmacological and psychotherapeutic interventions are included, as well as somatic non-pharmacological treatments. The chapter authors represent the leaders in their respective fields.
The Clinical and Ethical Practice of Neuromodulation – Deep Brain Stimulation and Beyond
Neuromodulation is among the fastest-growing areas of medicine, involving many diverse specialties and affecting hundreds of thousands of patients with numerous disorders worldwide. It can briefly be described as the science of how electrical, chemical, and mechanical interventions can modulate the nervous system function. A prominent example of neuromodulation is deep brain stimulation (DBS), an intervention that reflects a fundamental shift in the understanding of neurological and psychiatric diseases: namely as resulting from a dysfunctional activity pattern in a defined neuronal network that can be normalized by targeted stimulation. The application of DBS has grown remarkably and more than 130,000 patients worldwide have obtained a DBS intervention in the past 30 years—most of them for treating movement disorders. This Frontiers Research Topics provides an overview on the current discussion beyond basic research in DBS and other brain stimulation technologies. Researchers from various disciplines, who are working on broader clinical, ethical and social issues related to DBS and related neuromodulation technologies, have contributed to this research topic.
The Noonday Demon
WITH A NEW EPILOGUE BY THE AUTHOR Like Primo Levi's The Periodic Table, The Noonday Demon digs deep into personal history, as Andrew Solomon narrates, brilliantly and terrifyingly, his own agonising experience of depression. Solomon also portrays the pain of others, in different cultures and societies whose lives have been shattered by depression and uncovers the historical, social, biological, chemical and medical implications of this crippling disease. He takes us through the halls of mental hospitals where some of his subjects have been imprisoned for decades; into the research labs; to the burdened and afflicted poor, rural and urban. He talks to faith healers and voyages around the world in a quest for folk wisdom. He analyses the medications of today as well as reviewing the politics of diagnosis and treatment and, perhaps most significantly, he looks at the vital role of will and love in the process of recovery. **ONE OF THE GUARDIAN'S 100 BEST BOOKS OF THE 21st CENTURY**
Stereotactic and Functional Neurosurgery
This text presents a comprehensive and state-of the-art approach to stereotactic and functional neurosurgery. Overarching sections include achieving stereotactic precision, defining trajectories and targets, the biophysics of stereotactic therapies, diseases and targets, and the future of functional neurosurgery. Each section is designed to be inclusive of all relevant topics, serving as an unbiased resource to new clinicians in this field or established clinicians that are aiming to better understand complementary methods. Importantly, each section and the associated chapters can be used by basic and translational scientists as well as engineers and industry to better understand and deliver...
Interventional Psychiatry
Recent advances in pharmacology and brain stimulation have led to the development of novel treatments for psychiatric disorders. These new advances have led to the development of a new subspeciality, Interventional Psychiatry. Interventional Psychiatry: Road to Novel Therapeutics reviews all specialized treatments including device-based interventions such as electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), and deep brain stimulation (DBS). This book discusses the procedure-based pharmacologic interventions including ketamine infusion therapy and psychedelic therapies. Internationally contributed, each this book outlines the state of the field, as well as implications for training and the role of the interventional psychiatrist in treatment teams. - Introduces an innovative approach combining both well-established and innovative methodologies - Includes an in-depth description of putative mechanisms of action - Features clinician-friendly presentation of indications, contraindications, and techniques - Outlines guidelines to foster fellowships in Interventional Psychiatry
Managing Treatment-Resistant Depression
Managing Treatment-Resistant Depression: Road to Novel Therapeutics defines TRD for readers, discussing the clinical and epidemiological predictors, economic burden and neurobiological factors. In addition, staging methods for treatment resistance are fully covered in this book, including serotonin specific reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, other classes of antidepressants, including tricyclic antidepressants and monoamine oxidase inhibitors, augmentation strategies, and newer antidepressant treatments like ketamine and esketamine. In addition, evidence supporting the use of psychotherapies and neuromodulation strategies are also reviewed. Written by top experts in the field, this book is the first of its kind to review all methods of treatment for TRD. - Defines Treatment-Resistant Depression and Staging Treatment Intensity - Includes Treatment-Resistant Depression options for children, adolescents, geriatrics, during pregnancy, and during post-partum and menopause transitions - Discusses the use of Ketamine and Esketamine for treatment-resistant depression
The Pleasure Shock
The electrifying, forgotten history of Robert Heath's brain pacemaker, investigating the origins and ethics of one of today's most promising medical breakthroughs: deep brain stimulation The technology invented by psychiatrist Robert G. Heath in the 1950s and '60s has been described as among the most controversial experiments in US history. His work was alleged at the time to be part of MKUltra, the CIA's notorious "mind control" project. His research subjects included incarcerated convicts and gay men who wished to be "cured" of their sexual preference. Yet his cutting-edge research and legacy were quickly buried deep in Tulane University's archives. Investigative science journalist Lone Fr...
How Emotions Are Made
'How Emotions Are Made did what all great books do. It took a subject I thought I understood and turned my understanding upside down' – Malcolm Gladwell, author of The Tipping Point When you feel anxious, angry, happy, or surprised, what's really going on inside of you? Uncover fascinating insights into the human mind with How Emotions Are Made by Lisa Feldman Barrett, a pioneer in neuroscience and psychology. This profound book will dismantle and reconstruct your understanding of your own emotions. The world perceives our emotions as automatic and reactive, a response to the world around us. But How Emotions Are Made poses a compelling new perspective, suggesting emotions aren't universal...
New Oxford Textbook of Psychiatry
Over its two editions, The New Oxford Textbook of Psychiatry has come to be regarded as one of the most popular and trusted standard psychiatry texts among psychiatrists and trainees. Bringing together 146 chapters from the leading figures in the discipline, it presents a comprehensive account of clinical psychiatry, with reference to its scientific basis and to the patient's perspective throughout. The New Oxford Textbook of Psychiatry, Third Edition has been extensively re-structured and streamlined to keep pace with the significant developments that have taken place in the fields of clinical psychiatry and neuroscience since publication of the second edition in 2009. The new edition has b...
Late Life Depression, An Issue of Psychiatric Clinics
Apart from Alzheimer's dementia, depressive disorders are emerging to account for the next greatest share of disability among older adults. Depressive illnesses complicate the recovery of many important medical illnesses and are associated with suicide death in the elderly at rates exceeding those seen in young adults. This issue of Psychiatric Clinics provides information for general adult psychiatrists, internal medicine geriatricians, and primary care physicians and care extenders to enable them to meet the most basic needs of depressed older adults. Topics in this issue address the questions: What is late life depression? What are the unique cognitive deficits seen in late life depressio...
