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Thrombolytic Therapy for Acute Stroke
It often takes time for a new therapeutic modality to mature into an accepted treatment option. After initial approval, new drugs, devices, and procedures all go through this process until they become “vetted” by the scientific community as well as the medical community at large. Thrombolysis for treatment of stroke is no exception. Thrombolytic Therapy for Acute Stroke, Second Edition comes four years after the first edition and provides a very comprehensive, updated perspective on the use of intravenous rt-TPA in acute stroke. The authors provide longer term follow-up on the pivotal clinical trials that led to Food and Drug Administration approval, data concerning phase 4 trials in lar...
Thrombolytic Therapy for Stroke
Thrombolytic Therapy for Stroke is intended for physicians who will be treating patients in the first few hours after stroke: neurologists, neurosurgeons, emergency medicine physicians, internists, and radiologists. In some areas, fam ily medicine general practice physicians may provide the majority of acute stroke care. We will provide the reader with all the data necessary to understand the utility and limitations of thrombolytic therapy. By reading the protocols, and working through the case tutorials, the reader will become sufficiently familiar with the indications and contraindications of thrombolytic therapy to begin evalu ating potential patients. Although nothing can replace direct ...
Mitochondrial Function and Dysfunction
Mitochondria are critical to the survival of cells, therefore, it is not surprising that abnormalities in mitochondrial function may lead to human disease. This book concentrates on the biology and pathology of mitochondria, covering some ot the important basic science features of the biology of mitochondria. It then moves on to discuss the breadth of human diseases related to mitochondrial dysfunction, including Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Alzheimer's disease.* Provides comprehensive coverage of basic science and clinical features of mitochondrial dysfunction* Presents detailed analysis of "hot" topics in mitochondrial function and neurodegenerative diseases* Includes outstanding list of contributing authors
Translating Mechanisms of Orofacial Neurological Disorder
In this volume, members of the International Translational Research Network on Orofacial Neurological Disorders and invited experts provide authoritative overviews of new aspects of motor function and sensation relating to neurological disorders in orofacial regions. Orofacial movements constitute fundamental motor patterns with essential roles in consummatory behavior, self-care, defensive and attack behaviors, vocalization and, in higher mammals, verbal as well as non-verbal communication. Clinically, dysfunction in orofacial movement is evident in numerous dental, cranio-maxillo-facial and neuropsychiatric disorders, including dysphagia, Huntington's disease, Parkinson's disease and schizophrenia. - Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research - Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered - All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Monoamine Oxidases and their Inhibitors
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. In this volume, invited experts provide authoritative reviews on various aspects of Monoamine Oxidase and its Inhibitors. - Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research - Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered - All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a collection of articles covering Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders. Topics covered include molecular profiling of direct and indirect striatal medium spiny neurons, the role of epigenetics in development and function of basal ganglia and transgenic animal models for Parkinson's disease.
The Neurobiology of Multiple Sclerosis
Multiple sclerosis (MS) is an immune-mediated neurodegenerative disorder of the human central nervous system (CNS) which usually affects young adults with certain genetic backgrounds who are then exposed to certain precipitating environmental antigen(s). Despite major advances of the past two decades in understanding the pathophysiology of MS, and in spite of the introduction of new immunomodulatory and immuno-suppressive agents which may slow down disease progression and delay the onset of disability, the "cause and the "cure for MS remain elusive. This volume of International Review of Neurobiology focuses on MS and related disorders. The volume can be divided into various sections with the main emphasis on MS pathogenesis, clinical features and epidemiology, neuroimaging, and treatment. The ultimate goal of this book is to encourage further research into the pathogenesis of this elusive disease.
International Review of Neurobiology
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
Geriatric Neurology
Aging affects neurological function leading to neurological disease As society grows older, so do the neurological problems associated with aging. These can be new neurological deficits due to the aging process itself, or the effect of aging on already existing neurological conditions. Neurologists will spend increasing amounts of time managing patients with age-related neurological complications. Geriatric Neurology brings together the wisdom of world-leading experts. They have crafted a new textbook to define this emerging subspecialty from basic science through clinical assessment and medical management to social aspects of patient care. Geriatric Neurology covers: The aging brain in neurology Assessment of the geriatric neurology patient Neurological conditions in the elderly Therapeutics for the geriatric neurology patient Management issues beyond therapeutics Comprehensive in scope but with practical focus for effective patient care, Geriatric Neurology provides top-of-class guidance for the management of elderly patients with neurological disorders.
