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Chemoinformatics Approaches to Structure- and Ligand-Based Drug Design
Chemoinformatics is paramount to current drug discovery. Structure- and ligand-based drug design strategies have been used to uncover hidden patterns in large amounts of data, and to disclose the molecular aspects underlying ligand-receptor interactions. This Research Topic aims to share with a broad audience the most recent trends in the use of chemoinformatics in drug design. To that end, experts in all areas of drug discovery have made their knowledge available through a series of articles that report state-of-the-art approaches. Readers are provided with outstanding contributions focusing on a wide variety of topics which will be of great value to those interested in the many different and exciting facets of drug design.
Microbes at Bio/Nano Interfaces
Microbes at Bio/Nano Interfaces, Volume 54 in the Advances in Virus Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Advanced Hydrogel for Management of Bacterial Wound Infections, Biofilm Characterization: Imaging, analysis and considerations, Parasitic worm interactions with host molecular machinery, Investigation of microbes and surface carbohydrates using Atomic Force Microscopy, Interactions Between Microbial Cells and Titanium Implant Surfaces, Targeting Bacterial Polysaccharides with Antibodies and Vaccines, and much more. Other sections cover Using next generation sequencing to study host-pathogen interactions, Microbial Nano-Biosynthesis: Biomedical, Food and Environmental Applications, and Functional co-expression of LEA peptides: Providing an environment for efficient cellular recombinant protein expression.
Structural Glycobiology
Structural Glycobiology covers the experimental, theoretical, and alternative technologies used in the study of the structural basis for the diverse biological roles of carbohydrates. The book overviews the application of specialized technologies to the study of carbohydrates in biology, reviews relevant and current research in the field, and is il
Structural and Computational Glycobiology: Immunity and Infection
Interest in understanding the biological role of carbohydrates has increased significantly over the last 20 years. The use of structural techniques to understand carbohydrate-protein recognition is still a relatively young area, but one that is of emerging importance. The high flexibility of carbohydrates significantly complicates the determination of high quality structures of their complexes with proteins. Specialized techniques are often required to understand the complexity of carbohydrate recognition by proteins. In this Research Topic, we will focus on structural and computational approaches to understanding carbohydrate recognition by proteins involved in immunity and infection. Particular areas of focus include cancer immunotherapeutics, carbohydrate-lectin interactions, glycosylation and glycosyltransferases.
Flying Into Danger
A fascinating look at the troubled life story of wartime bravery, the price of fame and of a serious breakdown that lasted two decades.During the 1950s Paul Brickhill, an Australian fighter pilot, prisoner of war and author wrote, without a doubt, the best iconic stories of the RAF in wartime Europe - all tour-de-force books based on brilliant research which today remain unfaded. Most are still in print. Paul Brickhill may have been forgotten, but not his books and not the classical feature film versions derived from them.
Hearings
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Their Fathers' Land
In Egypt, in Gallipoli and in France, they are many who sleep beneath a small wooden cross and each cross will testify to people over there that we from downunder knew how to fight for a noble idea. In this WW1 novel, published in English for the first time, Jim and Dick are two lively boys from the bush, along with 20,000 other Australians and New Zealanders, who embarked on what seemed to be a great adventure when they enlisted in the 1st AIF - to fight for 'King and Empire'. Their experience is cut short when both are seriously wounded on the Gallipoli peninsula. They find themselves in beds next to each other on a hospital ship headed for England. As they slowly recover, they discover th...
