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The rewarding properties of drugs depend on their capacity to activate appetitive motivational states. Because the mechanisms underlying natural reward are an important life-sustaining process and strongly conserved throughout metazoan evolution, invertebrate models provide a powerful complement to the mammalian systems traditionally used in addiction research. A wide range of organizational complexity, combined with genetically manipulable, and relatively simple, accessible nervous systems, make invertebrates excellent models in which to explore general addiction principles. These include the role of natural reward systems in learning, the basic biological mechanisms of drug addiction, and ...
Each no. represents the results of the FDA research programs for half of the fiscal year.
The purpose of this book is to place a resource in the hands of experimental mechanics researchers to enable them to understand and to obtain a working familiarity with certain of the numerical methods particularly useful to the field. The book is organized to permit readers to study the methods and to observe their application in experimental problems. It is also intended to encourage readers to directly apply the methods to the same problems or to similar problems of their choosing. To this end, computer programs are available electronically, together with data, for easy application. Program listings are given in the appendix. There are four chapters which make up the central coverage of t...
This handbook is geared towards the following aims: Reviewing the state of research on disordered language perception and production in adults and children. Describing and discussing present attempts at modelling human language processing by using linguistic disorders and pathologies as a data base. Presenting diagnostic and therapeutic concepts. Pointing out gaps and inconcistencies in current knowledge and theories. In bringing together knowlegde of different sources and disciplines under a common roof, the editors have achieved a comprehensive overview of the state of the art in the field of language pathology. Because of the diversity of the disciplines contributing to this scientific fi...