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Offers a compendium of information on retrosynthesis and process chemistry, featuring innovative "reaction maps" showing synthetic routes of some widely used drugs This book illustrates how the retrosynthetic tool is applied in the Pharmaceutical Industry. It considers and evaluates the many viable synthetic routes that can be used by practicing industrialists, guiding readers through the various steps that lead to the "best" processes and the limits encountered if these are put into practice on an industrial scale of seven key Active Pharmaceutical Ingredient (API). It presents an evaluation of the potential each process has for implementation, before merging the two points of view—of ret...
Focusing on an important class of compounds in organic synthesis, this text features contributions by leading experts, and delivers the quality expected from the “Patai Series.”
This book on X-ray Crystallography is a compilation of current trends in the use of X-ray crystallography and related structural determination methods in various fields. The methods covered here include single crystal small-molecule X-ray crystallography, macromolecular (protein) single crystal X-ray crystallography, and scattering and spectroscopic complimentary methods. The fields range from simple organic compounds, metal complexes to proteins, and also cover the meta-analyses of the database for weak interactions.
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PLACAR: a maior revista brasileira de futebol. Notícias, perfis, entrevistas, fotos exclusivas.
PLACAR: a maior revista brasileira de futebol. Notícias, perfis, entrevistas, fotos exclusivas.
PLACAR: a maior revista brasileira de futebol. Notícias, perfis, entrevistas, fotos exclusivas.
Publicado em 1894, Rumorejos do Monte Himalaya é o primeiro livro da escritora Amelia Gomes de Azevedo (1866-1929). A obra, dividida em duas partes, contém textos publicados pela autora em diversos periódicos nacionais, bem como textos em francês. Desfilam, em suas narrativas, além de personagens fictícios, alguns personagens históricos como Cristóvão Colombo e D. Pedro II. Ao mesmo tempo que detectamos um forte componente do romantismo (personagens solitários e sofredores, índio cavalheiresco, exuberante paisagem tropical), também é possível encontrar pistas que apontam para um tempo de intensas transformações sociais, como a transição do trabalho escravo para o assalariado e da monarquia para a república. A Série Memórias Fluminenses busca recuperar com a obra esse nome feminino da literatura regional, com textos que nos trazem pistas sobre um período ainda pouco conhecido e pouco estudado da região noroeste fluminense, como foram as últimas décadas do século XIX.
This book reports on the latest research and developments in Biomedical Engineering, with a special emphasis on topics of interest and findings achieved in Latin America. This third volume of a 4-volume set covers advances in biomechanical analysis and modeling, neural network based methods for medical diagnosis and therapy, and robots and human-machine interface for rehabilitation. Throughout the book, a special emphasis is given to low-cost technologies and to their development for and applications in clinical settings. Based on the IX Latin American Conference on Biomedical Engineering (CLAIB 2022) and the XXVIII Brazilian Congress on Biomedical Engineering (CBEB 2022), held jointly, and virtually on October 24-28, 2022, from Florianópolis, Brazil, this book provides researchers and professionals in the biomedical engineering field with extensive information on new technologies and current challenges for their clinical applications. .