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Mesenchymal Stromal Cells
Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells. However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs. This ...
The Bethesda Handbook of Clinical Hematology
Written by clinicians and scientists at the National Institutes of Health and other leading institutions, The Bethesda Handbook of Clinical Hematology, Second Edition is a concise, complete hematology handbook designed for quick bedside consultation. The book covers all hematologic disorders and provides residents, fellows, and practitioners with need-to-know information on pathophysiology, natural history, risk factors, diagnosis, treatment, and follow-up. The succinct yet detailed presentation is ideal for board review as well as clinical reference. This thoroughly updated edition includes new information on supportive care and new therapies, including immunomodulatory drugs, growth factors, and epigenetic-acting agents and their role in selected disorders.
Mesenchymal Stromal Cells
Mesenchymal Stromal Cells: Translational Pathways to Clinical Adoption provides the latest information on the necessary steps for successful production of stem cells for a clinical trial. Written by professionals with hands-on experience in bringing MSC therapies to the clinic, and building on the biology and mechanisms of action, this unique book covers the development and production of clinical-grade products that are suitable for use in humans. From design of a cell production facility, to obtaining regulatory approval and reimbursement issues, it is a useful guide for researchers and administrators across biomedical research. - Provides methodologies for clinical MSC production, from designing a facility, to post-market approval - Includes real-life examples of MSC production in academic centers and MSC production for biopharmaceutical clinical trials - Offers a unique perspective on the clinical aspects of MSC studies - Presents the principles of clinical trials that can be applied to the production of various cell therapies
Cardiac Extracellular Matrix
This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM’s role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulat...
Biomaterials and Stem Cells in Regenerative Medicine
Work in the area of biomaterials and stem cell therapy has revealed great potential for many applications, from the treatment of localized defects and diseases to the repair and replacement of whole organs. Researchers have also begun to develop a better understanding of the cellular environment needed for optimal tissue repair and regeneration. Bi
Stem Cells and Human Diseases
The main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned. Overall, these reviews will provide a new understanding of the influence of stem cells in tissue regeneration, disease regulation, therapy and drug resistance in several human diseases.
Conn's Current Therapy 2010 E-Book
Conn's Current Therapy 2010 provides concise and easy-to-use guidance on the latest advances in therapeutics for common complaints and diagnoses. Edward T. Bope, MD; Robert E. Rakel, MD; and Rick D. Kellerman offer their expertise and the knowledge of hundreds of skilled international leaders on the full range of evidence-based management options. Tap into recent developments and thorough updates on myelodysplastic syndromes, psychocutaneous medicine, recently-approved and soon-to-be-approved drugs, and much more to stay on top of current treatment practices. With the full text online at expertconsult.com, you'll have the information you need right at your fingertips for easy access! Provide...
Peterson's Graduate Programs in Pathology & Pathobiology; Pharmacology & Toxicology; Physiology; and Zoology
Peterson's Graduate Programs in Pathology & Pathobiology; Pharmacology & Toxicology; Physiology; and Zoology contains a wealth of information on universities that offer graduate/professional degrees in these fields that include Molecular Pathogenesis, Molecular Pathology, Molecular Pharmacology, Molecular Toxicology, Cardiovascular Sciences, Molecular Physiology, and Animal Behavior. Up-to-date data, collected through Peterson's Annual Survey of Graduate and Professional Institutions, provides valuable information on degree offerings, professional accreditation, jointly offered degrees, part-time and evening/weekend programs, postbaccalaureate distance degrees, faculty, students, degree requ...
