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The Hsp60 Chaperonin
In this unique overview of the Hsp60 chaperonin, Peter Bross addresses molecular biologists, medical research scientists and individuals interested in molecular or general biology. First, Bross discusses the basics of the Hsp60 chaperonin in terms of its structure and the molecular mechanisms determining its function. Second, the author highlights the multiple roles of Hsp60 for cellular systems and regulatory pathways, especially in connection with neurodegenerative diseases caused by Hsp60 deficiency. Finally, the author highlights controversial observations suggesting additional, non-standard functions of Hsp60 in and outside mitochondria as well as possible gaps in our understanding of the chaperonin. This volume serves as a snapshot suitable for experienced researcher working in fields related to molecular chaperones yet still accessible to researchers entering the field.
Family Records
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Protein Misfolding and Disease
For decades it has been known that structured conformations are important for the proper functioning of most cellular proteins. However, appreciation that protein folding to the functional conformations as well as the structural maintenance of protein molecules are very complex processes has only emerged during the last ten years. The intimate interplay uncovered by this scientific development led us to realize that perturbations of the protein folding process and disturbances of conformational maintenance are major disease mechanisms. This development has given rise to the concept of conformational diseases and the broader signature of protein folding diseases, comprising diseases in which ...
Pathologic Conditions of the Human Nervous and Muscular Systems Associated with Mutant Chaperones: Molecular and Mechanistic Aspects
This eBook presents illustrative examples of genetic chaperonopathies affecting primarily nerves and muscles and discusses molecular mechanisms and treatment targeting chaperones, i.e., chaperonotherapy.
Family Records
With few exceptions, this work identifies every family that can be traced to the Passaic Valley prior to 1800. It is a massive compilation, treating several generations in the direct line, and it is surprisingly good in the elucidation of family relationships. Several years in preparation, this work names no fewer than 25,000 persons. The principal families covered are: Allen, Alward, Anderson, Badgley, Bailey, Ball, Barle, Bauldwell, Beach, Bebout, Bedell, Bedford, Bonnel, Boyle, Brittin, Broadwell, Brown, Burrows, Byram, Clark, Conklin, Connet, Cooper, Elmer, Enyart, Findlay, Finn, Frazee, French, Griffin, Hall, Hallock, Halsey, Hand, Hart, Heath, Hedges, High, Hill, Hole, Hurin, Jennings,...
Pennsylvania Archives
A collection of documents supplementing the companion series known as "Colonial records," which contain the Minutes of the Provincial council, of the Council of safety, and of the Supreme executive council of Pennsylvania.
JIMD Reports, Volume 27
JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
