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Technologies for Detection of DNA Damage and Mutations
Man-made carcinogens, natural genotoxic agents in the environment, as well as ionizing and ultraviolet radiation can damage DNA and are a constant threat to genome integrity. Throughout the evolution oflife, complex DNA repair systems have developed in all living organisms to cope with this damage. Unrepaired DNA lesions can promote genetic alterations (mutations) that may be linked to an altered phenotype, and, if growth-controlling genes are involved, these mutations can lead to cell transformation and the development of malignant tumors. Proto oncogenes and tumor suppressor genes may be critical targets for DNA damaging agents. In a number of animal model systems, correlations between exp...
Biological Reactive Intermediates V
Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive species, and then covalently react with cellular macromolecules to induce toxic and carcinogenic effects was an observation that spawned the research featured in the Fifth International Symposium on Biological Reactive Intermediates (BRI V). The grou...
Our Medical Future
An awe-inspiring timetable through the year 2030 of each medical advance that will eliminate both life-threatening disease and everyday ailments, from curing obesity to the approval of the first AIDS vaccine. Based on intensive research and privileged discussion with over 60 experts in specialized fields.
Oxidative Damage & Repair
This book was inspired by the presentations delivered at the Oxidative Damage & Repair Symposium (November, 1990). The book is organized into 20 chapters which mirror the 20 session topics of the Oxidative Damage & Repair Symposium.
