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Rediscovering the Immune System as an Integrated Organ
The mainstream view of the immune system is concerned with molecular and cellular details resulting in a picture of immense complexity. Many immunologists live with this complexity, hoping that a series of breakthroughs will eventually add up to a greater insight. However, the forest is ignored for the trees and a 'Systems Approach' is vital for a better understanding. Peter Bretscher develops here a unique perspective on how the immune system functions as an integrated organ, by taking account of observations and concepts at the 'level of system' that are often half forgotten or ignored. A colleague, on reading this book, wrote: "Those who have followed Peter's work these past 50 years will...
Newgrange and the Bend of the Boyne
The book is also concerned with the future of this protected cultural landscape and recommends actions to ensure its' preservation."--Cover.
House documents
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Bayesian Data Analysis
Winner of the 2016 De Groot Prize from the International Society for Bayesian AnalysisNow in its third edition, this classic book is widely considered the leading text on Bayesian methods, lauded for its accessible, practical approach to analyzing data and solving research problems. Bayesian Data Analysis, Third Edition continues to take an applied
Differential Geometry and Statistics
Several years ago our statistical friends and relations introduced us to the work of Amari and Barndorff-Nielsen on applications of differential geometry to statistics. This book has arisen because we believe that there is a deep relationship between statistics and differential geometry and moreoever that this relationship uses parts of differential geometry, particularly its 'higher-order' aspects not readily accessible to a statistical audience from the existing literature. It is, in part, a long reply to the frequent requests we have had for references on differential geometry! While we have not gone beyond the path-breaking work of Amari and Barndorff- Nielsen in the realm of application...
Steps Towards a Unified Basis for Scientific Models and Methods
Culture, in fact, also plays an important role in science which is, per se, a multitude of different cultures. The book attempts to build a bridge across three cultures: mathematical statistics, quantum theory and chemometrical methods. Of course, these three domains should not be taken as equals in any sense. But the book holds the important claim that it is possible to develop a common language which, at least to a certain extent, can create direct links and build bridges. From this point of departure, the book will be of interest to the following three types of scientists OCo statisticians, quantum physicists and chemometricians OCo and in particular, statisticians and physicists who are ...
Elements of Statistical Computing
Statistics and computing share many close relationships. Computing now permeates every aspect of statistics, from pure description to the development of statistical theory. At the same time, the computational methods used in statistical work span much of computer science. Elements of Statistical Computing covers the broad usage of computing in statistics. It provides a comprehensive account of the most important computational statistics. Included are discussions of numerical analysis, numerical integration, and smoothing. The author give special attention to floating point standards and numerical analysis; iterative methods for both linear and nonlinear equation, such as Gauss-Seidel method and successive over-relaxation; and computational methods for missing data, such as the EM algorithm. Also covered are new areas of interest, such as the Kalman filter, projection-pursuit methods, density estimation, and other computer-intensive techniques.
Statistical Issues in Drug Development
Statistical Issues in Drug Development The revised third edition of Statistical Issues in Drug Development delivers an insightful treatment of the intersection between statistics and the life sciences. The book offers readers new discussions of crucial topics, including cluster randomization, historical controls, responder analysis, studies in children, post-hoc tests, estimands, publication bias, the replication crisis, and many more. This work presents the major statistical issues in drug development in a way that is accessible and comprehensible to life scientists working in the field, and takes pains not to gloss over significant disagreements in the field of statistics, while encouragin...
Differential Geometrical Theory of Statistics
This book is a printed edition of the Special Issue "Differential Geometrical Theory of Statistics" that was published in Entropy
