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Coronavirus disease 2019 (COVID-19), produces the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with atypical pneumonia. This infection is a global health challenge producing post-acute sequelae of SARS-CoV-2 infection (PASC), including neuro-PASC in which direct or indirect invasion of the virus into the brain causes immune dysregulation, hormonal disorders, elevated cytokine levels due to immune reaction and chronic inflammation, direct tissue injury, and persistent low-grade infection. The COVID-19 induced-neuroinflammation promotes blood-brain barrier (BBB) disruption, access of antigens and inflammatory factors into the brain, as well as infection or immune-mediated resp...
First multi-year cumulation covers six years: 1965-70.
This handbook provides an indispensable overview of all essential aspects of industrial-scale inkjet printing. Inkjet printing, as a scalable deposition technique, has grown in popularity due to its being additive, digital, and contact-free. Given these advantages, the technology can now be used in stable and mature industrial-scale applications. As the mechanisms for inkjet printing have improved, so too have the versatility and applicability of this machinery within industry. The handbook's coverage includes inks, printhead technology, substrates, metrology, software, as well as machine integration and pre- and post-processing approaches. This information is complemented by an overview of ...
Substance P: From Pain to Cancer, a volume in the Molecular Mediators in Health and Disease: How Cells Communicate series, provides a complete discussion of substance P biology, its role in normal physiology and a variety of diseases.The volume provides an introduction to substance P and its pharmacology, followed by exploring its role across the human body including cardiovascular function, micturition, learning and memory, emesis, respiration and sleep. It then discusses the critical role of substance P in several disease states including acute brain injury, neurodegeneration, seizures, depression and anxiety, cancer, musculoskeletal disorders, and viral infection, including COVID-19. The ...
Abstracts of the Sixth International Congress of Pharmacology deals with papers submitted during the pharmacology congress held at Helsinki in 1975. This collection of papers deals with research and development in pharmacology and biotherapeutic drugs. The wide array of subjects deals with the therapeutic implications of controlled drug delivery and the methods of drug application, including pharmacological investigations on cell in a culture. The book also contains papers about the interactions of neurotransmitters and the hypothalamic releasing hormones and toxins as tools in receptor studies. Some papers also deal with behavioral pharmacology that covers drug dependence, narcotic analgesi...
Twenty major German cities have a total of twenty-four theatres specializing, at a high level of sophistication, in presenting light comedy. They have their own typical ambience, principles of artistic management and casting. There are playwrights, actors, directors and designers who work almost exclusively in the genre, called boulevard comedy, developing highly specialised approaches to their work. In almost all cases, the predominantly privately run boulevard comedy theatres in Germany have been able to attract larger audiences than municipal or state theatres in the same cities. The book provides a description and an analysis of this phenomenon, which is unique to Germany. Chapters focus on an analysis of ambience, artistic managers, artistic policies and artistic structures, on major characteristics of the plays presented on the stages of German boulevard comedy theatres, on aspects of translation and the cultural transfer of comedy and laughter and on aspects of production and reception, dealing in turn with actors, directors, media coverage and audiences.
Der Wiederaufbau der Kolner Messe in der ersten Nachkriegsdekade stellt eine auaergewohnliche unternehmerische Erfolgsstory dar. Er spielte sich im Spannungsfeld von wirtschaftlichen Nutzenerwagungen und nahezu unuberbruckbaren Hindernissen ab. Letztere pragten den Weg von der Entscheidung, in Koln nach dem Krieg weiterhin eine Messe zu betreiben, bis hin zu den weltbedeutenden Veranstaltungen der 50er Jahre. Kommunale und landespolitische Zwangslagen der zerstorten Dommetropole, der Widerstand der Besatzungsmacht, der harte Wettbewerb der ehemaligen Messestadte untereinander, die Messepolitik als Spielball der deutschen Wirtschaftspolitik - all dies hinderte die Verfechter des Messegedanken...