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Psychiatric Institutions and Society
The book probes how the serious and sometimes fatal decision was made to admit individuals to asylums during Germany’s age of extremes. The book shows that - even during the Nazi killing of the sick - relatives played an even more important role in most admissions than doctors and the authorities. In light of admission practices, this study traces how ideas about illness, safety, and normality changed when the Nazi regime collapsed in 1945 and illuminates how closely power configurations in the psychiatric sector were linked to political and social circumstances.
The Gypsies During the Second World War
This is the third of three volumes, based on the latest research into the racial theories which underlay the suffering of the gypsies in the Holocaust and their fate in the death camps in the occupied countries of Hitler's Europe.
cGMP: Generators, Effectors and Therapeutic Implications
After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.
Nazi Ideology and Ethics
This volume documents the still-rare encounter of moral-philosophical, historiographic and medical-ethical research on National Socialism, and looks at the ethical aspects of the National Socialist ideology, as well as at the moral convictions of National Socialist perpetrators, some of whom acted as “perpetrators with a good conscience”. It furthermore discusses questions such as the content and rationale of Nazi race ethics, the “euthanasia” killings and the Nazi ethics of racial warfare and the role of the SS as the vanguard of the National Socialist race state, the moral conditioning of Nazi perpetrators and their self-exoneration strategies after the defeat of Nazism, and German...
Preservation in Digital Cartography
This book “Preservation in Digital Cartography: Archiving Aspects” should give an overview on how to preserve digital cartographic appli- tions and geospatial data in a sustainable way. The intention of this book is to shape the opinion of affected parties and to bring together various d- ciplines. Therefore adjacent chapters will generally deal with information technologies, Service-Oriented Architectures, cybercartography, reprod- tion and historic cartography, which all together can be subsumed in p- spective cartographic heritage. The survival of this digital cartographic heritage will base on long-term preservation strategies that make use of - tensive dissemination on the one hand ...
The Question of Unworthy Life
The dark history of eugenic thought in Germany from the nineteenth century to today—and the courageous countervoices Between 1939 and 1945, Nazi genocide claimed the lives of nearly three hundred thousand people diagnosed with psychiatric illness or cognitive deficiencies. Not until the 1980s would these murders, as well as the coercive sterilizations of some four hundred thousand others classified as “feeble-minded,” be officially acknowledged as crimes at all. The Question of Unworthy Life charts this history from its origins in prewar debates about the value of disabled lives to our continuing efforts to unlearn eugenic thinking today. Drawing on a wealth of rare archival evidence, ...
Silence, Scapegoats, Self-reflection
Since the end of World War II, Nazi medical atrocities have been a topic of ambivalent reactions and debates, both in Germany and internationally: An early period of silence was followed by attempts of victims and representatives of medical organisations to describe what happened. Varying narratives developed, some of which had a stabilizing function for the identity of the profession, whereas others had a critical and de-stabilizing function. In today's international debates in the field of medical ethics, there are frequent references to Nazi medical atrocities, in particular in the context of discussions about research on human subjects, and on euthanasia. The volume analyses the narratives on Nazi medical atrocities, their historicity in different stages of post-war medicine, as well as in the international discourse on biomedical ethics.
Reactive Oxygen Species
Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach ...
Recognizing the Past in the Present
Following decades of silence about the involvement of doctors, medical researchers and other health professionals in the Holocaust and other National Socialist (Nazi) crimes, scholars in recent years have produced a growing body of research that reveals the pervasive extent of that complicity. This interdisciplinary collection of studies presents documentation of the critical role medicine played in realizing the policies of Hitler’s regime. It traces the history of Nazi medicine from its roots in the racial theories of the 1920s, through its manifestations during the Nazi period, on to legacies and continuities from the postwar years to the present.
Contemporary Accounts in Drug Discovery and Development
CONTEMPORARY ACCOUNTS IN DRUG DISCOVERY AND DEVELOPMENT A useful guide for medicinal chemists and pharmaceutical scientists Drug discovery is a lengthy and complex process that typically involves identifying an unmet medical need, determining a biological target, chemical library screening to identify a lead, chemical optimization, preclinical studies and clinical trials. This process often takes many years to complete, and relies on practitioners’ knowledge of chemistry and biology, but also—and perhaps more importantly—on experience. Improving the success rate in discovery and development through a thorough knowledge of drug discovery principles and advances in technology is critical...
