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Why Vaccines to HIV, HCV and Malaria Have So Far Failed - Challenges to Developing Vaccines against Immunoregulating Pathogens
Despite continuous progress in the development of anti-viral and anti-bacterial/parasite drugs, the high cost of medicines and the potential for re-infection, especially in high risk groups, suggest that protective vaccines to some of the most dangerous persistent infections are still highly desirable. There are no vaccines available for HIV, HCV and Malaria, and all attempts to make a broadly effective vaccine have failed so far. In this Research Topic we look into why vaccines have failed over the years, and what we have learn from these attempts. Rather than only showing positive results, this issue aims to reflect on failed efforts in vaccine development. Coming to understand our limitations will have theoretical and practical implications for the future development of vaccines to these major global disease burdens.
Nanoscience in Medicine Vol. 1
This book takes a systematic approach to address the gaps relating to nanomedicine and bring together fragmented knowledge on the advances on nanomaterials and their biomedical applicability. In particular, it demonstrates an exclusive compilation of state of the art research with a focus on fundamental concepts, current trends, limitations, and future directions of nanomedicine.
Chemistry and Biology of Pteridines and Folates
The pteridines in their multitude of forms fulfill many roles in nature ranging from pigments to cofactors for numerous redox and one-carbon transfer reactions. This extraordinary diversity of function is unified by the unique chemistry of the pteridine heterocycle. The International Symposium on the Chemistry and Biology of Pteridines and Folates is a forum for presenting recent and exciting advances in this expanding field. In of ideas results that has often stimulated bringing together various disciplines, a synergy fresh approaches to major problems. The Tenth International Symposium held at Orange Beach, Alabama, March 21-23, 1993, proved no exception by providing new insights into fola...
Biotechnology Annual Review
Biotechnology is a diverse, complex and rapidly evolving field. Students and experienced researchers alike face the challenges of staying on top of developments in their field of specialty and maintaining a broader overview of the field as a whole. Volumes containing competent reviews on a diverse range of topics in the field fulfill the dual role of broadening and updating biotechnologists knowledge. The current volume is an excellent example of such a book. The topics covered range from classical issues in biotechnology - such as, vehicles for the production of biotechnology products and methods for their detection, separation and analysis - to topics that are focused on the role of biotechnology in the health sciences. The information presented in this book will therefore will be of great value to both experienced biotechnologists and biotechnologists in training.
Methods in Recombinant Protein Production
Methods in Microbiology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Methods in Microbiology serials - Updated release includes the latest information on Methods in Recombinant Protein Production
Fasciolosis, 2nd Edition
Fasciolosis is a major global infection of livestock causing both huge losses to the agricultural community and affecting human health as a food-borne disease. Fully updated throughout, this new edition continues to cover the life cycle, biology, and development of the parasite; clinical pathology, immunology, diagnosis and vaccine development; and emergence, cause and mechanisms of drug resistance. It reviews the temperate liver fluke Fasciola hepatica, together with molecular, biochemical, control, and epidemiologial aspects of the tropical liver fluke F. gigantica. Many fundamental advances have taken place in the last two decades, but of particular importance has been the mapping of the draft genome of Fasciola. In addition, comprehensive advances in transcriptomics, proteomics and glycomics have been made, and the book therefore pays particular attention to these developments with the addition of brand-new chapters. Also covering the impact these parasites have had on the global human population, their distribution and their ecology, this book provides a comprehensive and accessible resource for scientists, researchers and students of medical and veterinary parasitology.
Advanced Vaccination Technologies for Infectious and Chronic Diseases
The role of vaccines is emerging and even critical to ending infectious and chronic diseases and pandemics alike. The design and development of new vaccines could lead to improved health. Handbook on Advanced Vaccination Technologies for Infectious and Chronic Disease discusses these new developments and introduces the reader to the current state of the science and the outlook going forward from the discovery of vaccines to the clinical trials of personalized vaccines. Handbook on Advanced Vaccination Technologies for Infectious and Chronic Diseases is a valuable reference for occupational health professionals whose role involves supervision of immunization programs such as those working in ...
Microbial Nanotechnology
This book provides an account of the biogenic synthesis of nanomaterials by using different microorganisms. The chapters are focused on the biosynthesis of various metal and metal oxide nanosized materials by using bacteria, actinomycetes, fungi, and algae, including mechanisms of microbial synthesis. Other chapters summarize recent developments of microbial-based nanostructures for the management of food-borne pathogens, plant pathogenic fungi, as nutrients, and biomedical applications. Microorganisms are discussed not only as biofactories for the synthesis of nanomaterials but also as removal agents of toxic metals from the environment. Exposure sources and ecotoxicity of microbially synthesized nanoparticles are also discussed.
