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Genomic “dark matter”: implications for understanding human disease mechanisms, diagnostics, and cures
The vast majority of the human genome has been historically ignored from the point of view of molecular mechanisms of disease, diagnostics and potential therapeutic targets. The predominant focus of disease research has traditionally been placed on the protein-coding regions of the human genome, which account for only ~4-5% of its total sequence complexity. This bias has an obvious underlying reason: protein-coding regions encode a crucial class of molecules in a cell, whose function and importance are well established. Furthermore, proteins are the predominant class of cellular molecules against which effective therapeutics can be designed. This bias pervades the design of analytical tools ...
RNA Diseases in Humans – From Fundamental Research to Therapeutic Applications
This Research Topic addresses the human diseases caused by a malfunction of the RNA metabolism. We aim at strengthening the link between fundamental research and therapeutic applications. In eukaryotes, RNA is transcribed from genomic DNA. RNA molecules undergo multiple post-transcriptional processes such as splicing, editing, modification, translation, and degradation. A defect, mis-regulation, or malfunction of these processes often results in diseases in humans, referred to as 'RNA diseases'. There is an increasing number of studies focused on RNA diseases, which are aimed at uncovering the fundamental molecular mechanisms at play in order to develop therapeutic approaches.
Genetics and Philosophy
In the past century, nearly all of the biological sciences have been directly affected by discoveries and developments in genetics, a fast-evolving subject with important theoretical dimensions. In this rich and accessible book, Paul Griffiths and Karola Stotz show how the concept of the gene has evolved and diversified across the many fields that make up modern biology. By examining the molecular biology of the 'environment', they situate genetics in the developmental biology of whole organisms, and reveal how the molecular biosciences have undermined the nature/nurture distinction. Their discussion gives full weight to the revolutionary impacts of molecular biology, while rejecting 'genocentrism' and 'reductionism', and brings the topic right up to date with the philosophical implications of the most recent developments in genetics. Their book will be invaluable for those studying the philosophy of biology, genetics and other life sciences.
Recent Progresses of Non-Coding RNAs in Biological and Medical Research, 2nd Edition
Publisher’s note: In this 2nd edition, the following article has been updated: Xun Y, Tang Y, Hu L, Xiao H, Long S, Gong M, Wei C, Wei K and Xiang S (2019) Purification and Identification of miRNA Target Sites in Genome Using DNA Affinity Precipitation. Front. Genet. 10:778. doi: 10.3389/fgene.2019.00778
In Search of Unity
Albert Einstein once wrote: "The supreme task of the physicist is to arrive at those universal laws from which the cosmos can be built up by pure deduction." Remarkably, in this book we arrive at those universal axioms from which universal science can be built up by pure deduction. Within the prevailing paradigm of science - the mathematical philosophy of nature - we show it is not possible to unify science. To overcome this limitation we introduce a new, more general paradigm. Since the new paradigm is a generalisation of the mathematical philosophy of nature, we are able to retain the mathematical knowledge built up within the prevailing paradigm. Within the new paradigm we introduce four ...
The Future of Genetics
The Future of Genetics considers where research in genetics, molecular biology, and medicine is headed while trying to cleanly separate facts from fiction and ideologies. This new volume explores the last 150 years and how different strands of biological research have become interwoven to create a new kind of interdisciplinary science.
Drawing the Map of Life
Drawing the Map of Life is the dramatic story of the Human Genome Project from its origins, through the race to order the 3 billion subunits of DNA, to the surprises emerging as scientists seek to exploit the molecule of heredity. It's the first account to deal in depth with the intellectual roots of the project, the motivations that drove it, and the hype that often masked genuine triumphs. Distinguished science journalist Victor McElheny offers vivid, insightful profiles of key people, such as David Botstein, Eric Lander, Francis Collins, James Watson, Michael Hunkapiller, and Craig Venter. McElheny also shows that the Human Genome Project is a striking example of how new techniques (such as restriction enzymes and sequencing methods) often arrive first, shaping the questions scientists then ask. Drawing on years of original interviews and reporting in the inner circles of biological science, Drawing the Map of Life is the definitive, up-to-date story of today's greatest scientific quest. No one who wishes to understand genome mapping and how it is transforming our lives can afford to miss this book.
Genome Research
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