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Chromatin and Disease
This book includes a collection of articles with the broad theme of disease connection to chromatin structure and function. It elaborates on the molecular pharmacology of the drugs targeting chromatin structure and its components. The book contains up-to-date information about the chromatin structure and chromatin related diseases and drug functions. This work is the first endeavor to present different aspects encompassing the above theme.
The Abolition of Prison
The Abolition of Prison provides a reflection from a longtime prison abolitionist, psychoanalyst, and former prisoner on the history, theory, and practice of anti-prison activism in France and globally over the last fifty years. This book powerfully makes the case for the end of prisons, punishment, and guilt and, instead, suggests we work towards social change, care, collectivity. The book weaves together Lesage de La Haye’s own experiences—in prison, as a psychiatrist, and as a social theorist—with the simple argument that, if we take the reasons for prison and punishment at their word, we must evaluate the system as a complete failure. So then why continue to support it and funnel money into it?
Epigenetics: Development and Disease
Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.
Seven Deadly Sins
None
The Nucleolus
Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include both newly-discovered functions and aspects of its conventional role. The Nucleolus is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus.
Reckless
Luis Ocaña seemed doomed to live in the shadow of cycling's greatest ever rider, Eddy Merckx – 'The Cannibal'. Their rivalry defined Ocaña's entire career, yet he was the one rider capable of beating the all-conquering Merckx in his prime. After an impoverished upbringing he flourished at the sport he loved and in 1970 secured his biggest victory on home soil, winning the Vuelta a España, and confirming his status as a Grand Tour challenger. But it was in the 1971 Tour de France that the battle between Merckx and Ocaña reached its peak when, at the Orcières-Merlette stage, he inflicted on Merckx the worst defeat he would suffer in a major Tour, with an astonishing 120 kilometre solo b...
A Clean Break
The autobiography of cycling's Mr Clean who refused to dope or to remain silent about doping - and was exiled from the sport
The No-Drop Zone
The No-Drop Zone contains all the information necessary for new cyclists to gain the knowledge and skills to take them from buying their first bicycle to starting their first race. Cyclists learn how to handle the bike, perform minor maintenance, select clothing and accessories, join clubs, and find events. The book also covers every aspect of riding in a group, emphasizing such specific skills as how to avoid bumping into other riders when riding in close quarters and fixing a flat quickly enough to rejoin the group. Author Patrick Brady explores the particular pleasures that come from group riding, a unique experience at once social (talking with friends while riding), exciting (descending in a group), and exhilarating (finishing a long hill). Brady also details the enormous fitness benefits of riding in a group. The No-Drop Zone has all the knowledge a cyclist needs to move to that next level of skill.
DNA'Protein Interactions
Dr. Tom Moss assembles the new standard collection of cutting-edge techniques to identify key protein-DNA interactions and define their components, their manner of interaction, and their manner of function, both in the cell and in the test tube. The techniques span a wide range, from factor identification to atomic detail, and include multiple DNA footprinting analyses, including in vivo strategies, gel shift (EMSA) optimization, SELEX, surface plasmon resonance, site-specific DNA-protein crosslinking, and UV laser crosslinking. Comprehensive and broad ranging, DNA-Protein Interactions: Principles and Protocols, 2nd Edition, offers a stellar array of over 100 up-to-date and readily reproducible techniques that biochemists and molecular, cellular, and developmental biologists can use successfully today to understand DNA-protein interactions.
The Badger
The definitive biography of France's greatest cyclist by the number one bestselling author of Merckx: Half Man, Half Bike. Bernard Hinault is one of the greatest cyclists of all time. He is a five-time winner of the Tour de France and the only man to have won each of the Grand Tours on more than one occasion. Three decades on from his retirement, he remains the last Frenchman to win the Tour de France. His victory in 1985 marks the turning point when the nation who had dominated the first eight decades of the race they had invented suddenly found they were no longer able to win it. Hinault is the last 'old-school' champion: a larger-than-life character from a working-class background, capabl...
