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The Nramp Family
This book is the first comprehensive volume on the "Nramp family", highlighting the physiological importance of Nramp proteins as metal transporters. The molecular knowledge of these membrane proteins is presented from an evolutionary perspective, considering Nramp cellular function and mechanism of transport in key model organisms. The pathological significance of Nramp genetic polymorphism is discussed with emphasis on metal homeostasis and microbial infection. The chapters were contributed by leading investigators, providing a timely state of the art book in this rapidly growing field. The Nramp Family will be useful to a broad community of scientists interested in metal transport and molecular biology. It will be of interest to the research audience in the broad fields of metal ions and molecular medicine.
Setting Priorities in the Age of Austerity
Examines the British, French, and German armies’ approaches to accommodating significant budget cuts while attempting to sustain their commitment to full spectrum operations. Specifically, it looks at the choices these armies are making with respect to how they spend dwindling resources: What force structure do they identify as optimal? How much readiness do they regard as necessary? Which capabilities are they abandoning?
Susceptibility to Infectious Diseases
In the last ten years, substantial progress has been made in identifying why some people are particularly susceptible to specific infectious diseases. Extensive evidence has now accumulated that host genes are important determinants of the outcome of infection for many common pathogens. This book, written by leading authorities, summarises the advances which have been made in understanding the complexity of host genetic susceptibility. The diseases covered include those of great public health inportance such as malaria and HIV, and those of current topical interest such as Creutzfeldt-Jakob disease.
Decoding the Genomic Control of Immune Reactions
This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections. The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend. Specific problems addressed include the following: What kinds of information are we lacking to understand how the g...
Modern France and the World
Modern France and the World provides an engaging global history of the key events of modern France and its empire. It moves beyond the traditional political narrative of the development of the French Republican nation-state to offer both national and international perspectives of its evolution. The volume illustrates the integral exchanges that have taken place between France and the modern world, from global trade in the eighteenth century to the impact of postcolonial immigration and globalization on French identity and on France’s diverse population. It includes the voices of women, colonized populations, and those who both embraced and challenged the spread of French ideas and values around the globe. Drawing on methodologies of social, cultural, and gender history, this textbook integrates a wide range of analytical tools to entice readers to engage more deeply in France’s dynamic global history. By presenting the history of France and its global engagements from the mid-seventeenth century to the present, this volume is an essential resource for all students who study the history, politics, and culture of modern France.
Phagocytosis: The Host
An accompanying volume (Volume 6) in this series presents strategies of cellular invasion from the viewpoint of the microbe.This filed of study is growing rapidly after a somewhat slow start over recent decades. This collection of invited chapters attempts to reflect current research, and brings together cell biologists, microbiologists and immunologists with disparate interests. However, there is a certain unity, even repetition of key themes, hopefully like a symphony rather than a boring catalogue. It will be evident that editorial bias favors intracellular paratism and medically important organisms. The neutrophil is far more than a supporting player to the macrophage, and some attempt is made to remind the reader of some of its unique skills. To retain a manageable size, the emphasis is on relatively early events such as mutual recognition, cell entry, and response, rather than on longterm changes in gene expression by either host cell or pathogen. Viruses are excluded not because of lack of importance but because of somewhat different research approaches, although it is cytogenes, share common strategies in invasion and intercellular spread.
Molecular Biology of Hematopoiesis 6
This volume of Molecular Biology of Hematopoiesis is dedicated to many inter national scientists and clinicians for their contribution to the field of Hematology/ Oncology presented at the 11th International Symposium on Molecular Biology of Hematopoiesis, which was held in Bormio, Italy, June 25-29, 1998. The continuous support of the Presidents of the meeting, Professor F. Takaku, President of Jichi University, and E. D. Thomas, Nobel Laureate, was greatly acknowledged, especially Professor Takaku, for his vision and support for development of gene therapy in Japan. New information on BMT for autoimmune disease and organ transplantation was presented at the symposium and is published in th...
Data Driven e-Science
ISGC 2010, The International Symposium on Grid Computing was held at Academia Sinica, Taipei, Taiwan, March, 2010. The 2010 symposium brought together prestigious scientists and engineers worldwide to exchange ideas, present challenges/solutions and to discuss new topics in the field of Grid Computing. Data Driven e-Science: Use Cases and Successful Applications of Distributed Computing Infrastructures (ISGC 2010), an edited volume, introduces the latest achievements in grid technology for Biomedicine Life Sciences, Middleware, Security, Networking, Digital Library, Cloud Computing and more. This book provides Grid developers and end users with invaluable information for developing grid technology and applications. The last section of this book presents future development in the field of Grid Computing. This book is designed for a professional audience composed of grid users, developers and researchers working in the field of grid computing. Advanced-level students focused on computer science and engineering will also find this book valuable as a reference or secondary text book.
Oceans
Oceans The New Frontier explores how human community insistently pushes the oceans' limits, seeking to exploit all of their varied resources minerals, fisheries, fuels and genetic material. The ocean frontier is constantly being redefined by new discoveries, technologies, national strategies, and ecological imperatives. Increasing dependence of humanity on the resources of the oceans has blurred the boundaries between the mainland and oceans.As humanity's footprint extends, oceans are seeing intense conflicts between actors and issues. The book questions the ability of global governance to regulate access to resources and services provided by the oceans so as to protect the ocean ecosystems. The chapters show how the global governance system has not been adequately responsive while in many cases local initiatives have contributed the solutions. Special sites, like sea-ports, can provide levers for action.Oceans The New Frontier is part of a series of annual publications on sustainable development (A Planet for Life) prepared under the scientific leadership of leading figures in the field of sustainable development.
Genetic Susceptibility to Infectious Diseases
Infectious diseases are commonly regarded as a distinct category, with different causes and patterns than chronic or genetic disease. But in fact there are many varieties of genetic susceptibility to infection, the subject of this book, which will be divided into three sections: 1) concepts and methods, 2) genes and pathophysiologic mechanisms, and 3) infectious agents and diseases. No currently plubished text on either genetics or infectious diseases focuses on the genetic aspects of the special relationship between host and pathogen in the way envisioned for Section 1. No other work on the selected genes regulating immunity deals as systematically with the sequence variation/function relationships most pertinent to infection as planned for Section 2. And no other book gives as meaningful a picture of how these genes operate in infectious disease as Section 3 will.
