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Bacterial Virulence
Starting with basic principles, this reference and handbook discusses examples of the most advanced models of bacterial infection with regard to their value as paradigms to understand the molecular cross-talks between microbes and their host and tissue targets. It adopts a very forward-looking, advanced approach, placing special emphasis on the main global challenges facing scientists today, such as pathogenicity vs. commensalisms, infections in immunocompromised hosts and species specificity issues.
Bacteria and Intracellularity
Bacteria and Intracellularity clearly demonstrates that cellular microbiology as a field has reached maturity, extending beyond the strictly cellular level to infections of various organs and tissues. Decades of intense investigation into host-bacterial pathogen interactions have highlighted common concepts in intracellularity but also very diverse mechanisms underlying the various infections produced by bacteria. This book offers a wide-ranging look at the latest studies, including: foodborne pathogens, including how, when, and where bacteria interact with the gut and its microbiota infections of the urogenital tract, endothelial barriers, and the nervous system major advances in work with ...
Bacterial Membrane Vesicles
This book focuses on the multitude of functions bacterial membrane vesicles perform in bacterial ecology and pathogenesis as well as in emerging medical and biotechnological applications. Both Gram-negative and Gram-positive bacteria produce membrane-bound nanostructures, known as membrane vesicles, which have a range of functions that include serving as delivery vehicles, providing a means of communication over both spatial and temporal scales, and contributing to bacterial survival and evolution. Topics covered in this book range from the biogenesis and composition of bacterial membrane vesicles to their abundance and biological roles in microbial ecosystems, such as marine environments. I...
Mucosal Immunology
Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. Most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective, and excellent organization. It covers immune system topics, such as inductive and effector tissues and cells, and development and physiology of the mucosal barrier; diseases in the digestive system, respiratory tract, and genitourinary tract; and immunodeficiency. - The most comprehensive text on mucosal immunology from internationally recognized experts in the field - Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases - Contains nine new chapters and an expanded appendix
Pseudomonas
This volume collects new information on the genomics of saprophytic soil Pseudomonas, as well as functions related to genomic islands. It explores life styles in different settings and sheds further insights on the wide metabolic potential of this microbe for the removal of pollutants and production of added-value products. This volume also explores how Pseudomonas responds and reacts to environmental signals, including detection of cell density.
Effector-Triggered Immunity
This volume presents a collection of protocols to study effector-triggered immunity (ETI) in both plants and animals from eminent groups in the field. The chapters in this book cover topics such as genetic manipulation of plant and animal pathogens, host cells, and the analysis of key host responses; and techniques used for the analysis of inflammasome activation, cell death pathways, and mitochondria damage in response to pathogens. All of these topics cover a broad spectrum of immunological, biochemical, cell biological, and structural biology approaches to examine ETI. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Effector-Triggered Immunity: Methods and Protocols is a valuable resource for both expert and novice researchers who are interested in learning more about the important and developing field of ETI.
Endocytosis
(Director: Pierre J. COURTOY) Two years after its first gathering in Oeiras, Portugal, the European Endocytosis Group convened for a second workshop at the Pasteur Institute, Paris, on October 1-5, 1990. The meeting is reported in detail in this volume; a preliminary coverage, based on the overviews of each session, has appeared in the New Biologist (1991, 3:243-252). The three main objectives, to broaden the audience, to present a more comprehensive view of the multiple aspects of endocytosis, from basic biology to health, disease and therapy, as well as to clarify controversial issues, have been largely fulfilled. The Second European Workshop on Endocytosis was attended by more than tOO participants, originating from 18 countries. 59 lectures and 35 posters were presented. In addition, vivi~ roundtables allowed to thoroughly discuss the dynamics and the regulation of the endocytic apparatus, as well as the role of endocytosis in antigen presentation. Endocytosis is a general and distinctive property of all eukaryotic cells, including protists, plants and fungi.
Intracellular Niches of Microbes
The book describes the different and exciting pathways which havebeen developed by pathogenic microbes to manage living inside hostcells. It covers intracellular life styles of all relevantpathogenic but also symbiotic microorganisms with respect to thecell biology of the host-microbe interactions and the microbialadaptations for intracellular survival. It features intracellulartrafficking pathways and characteristics of intracellular niches ofindividual microbes. The book also asks questions on the benefitsfor the microbe with regard to physiological needs and nutritionalaspects such as auxotrophy, effects on genome sizes, andconsequences for disease and host response/immunity (and thebenefits for the host in the cases of symbionts). Additionally, the book includes those pathogens that are medicallyless important but represent distinct intracellular niches,trafficking behaviours and virulence traits. The individualchapters also point out future challenges of research for therespective organism.
