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Deciphering the T Cell Response in SARS-CoV-2 Infection
COVID-19 is a recently emerged infectious disease caused by the novel coronavirus SARS-CoV-2. The immune system has a primary role in pathogen elimination and a rapid and effective response can limit disease severity. In this context, T cells play the major role in cell mediated adaptive immune response. The protective role of CD4+ and CD8+ T cells has been inferred from studies on patients who recovered from SARS and MERS and accumulating data are now showing their relevance in SARS-CoV-2 infection. Moreover, memory T cells induced by previous pathogens can shape the susceptibility to, and the clinical severity of other infections, but the complete picture has yet to be elucidated. If the virus is not rapidly eliminated, COVID-19 may progress towards a secondary inflammatory phase that is directly responsible for a worsening in clinical symptoms and immune system impairment. Besides marked lymphopenia, COVID-19 patients’ T cell compartment displays several alterations involving different subpopulations of T cells in terms of phenotype, metabolic profile and functionality.
Cancer Immunotherapy Meets Oncology
This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
Ménage à Trois
Met de aanstelling van een hoogleraar gynaecologische oncologie als hoofd van het Centrum Gynaecologische Oncologie Amsterdam is er een samenwerkingsverband tussen de afdelingen van het AMC, NKI-AVL en VUmc ontstaan. Door deze samenwerking zullen patiënten, medewerkers en onderzoekers naar verwachting voordelen ervaren in de vorm van betere kwaliteit en hogere efficiency. In deze oratie worden enkele voorbeelden genoemd van de voordelen voor de patiëntenzorg, evenals de keuzes die worden gemaakt in het wetenschappelijk onderzoek. Verschillende scenario’s worden besproken waarin de samenwerking gestalte kan krijgen.
Flow Cytometry and Cell Sorting
The analysis and sorting of large numbers of cells with a fluorescence-activated cell sorter (FACS) was first achieved some 30 years ago. Since then, this technology has been rapidly developed and is used today in many laboratories. A Springer Lab Manual Review of the First Edition: "This is a most useful volume which will be a welcome addition for personal use and also for laboratories in a wide range of disciplines. Highly recommended." CYTOBIOS
The Land of Short Sentences
A young mother follows her partner to a rural community in West Jutland, Denmark, where he teaches at the local school for adult education. Isolated, she is forced to find her way in a bewildering community and in the inscrutable conversational forms of the local population. A young woman relocates to an outlying community in West Jutland, Denmark, and is forced to find her way, not only in the bewildering environment of the residential Folk High School, where her partner has been hired to teach, but also in the inscrutable conversational forms of the local population. And on top of it all there's the small matter of juggling her roles as mother to a newborn baby and advice columnist in the local newspaper. In this understated and hilarious novel, Stine Pilgaard conjures a tale of venturing into new and uncharted land, of human relationships, dilemmas, and the ways and byways of social intercourse.
Bioinformatics and Systems Biology
Collaborative research in bioinformatics and systems biology is a key element of modern biology and health research. This book highlights and provides access to many of the methods, environments, results and resources involved, including integral laboratory data generation and experimentation and clinical activities. Collaborative projects embody a research paradigm that connects many of the top scientists, institutions, their resources and research worldwide, resulting in first-class contributions to bioinformatics and systems biology. Central themes include describing processes and results in collaborative research projects using computational biology and providing a guide for researchers to access them. The book is also a practical guide on how science is managed. It shows how collaborative researchers are putting results together in a way accessible to the entire biomedical community.
Bioinformatics and Computational Biology
Proceedings of the 2019 International Conference on Bioinformatics & Computational Biology (BIOCOMP'19) held July 29th - August 1st, 2019 in Las Vegas, Nevada.
Flow Cytometry and Sorting
Revised and updated, this Second Edition of a classic text describes and evaluates--in greater detail--the most recent practical applications of flow cytometry technique to basic cellular biological investigations and clinical research on human neoplasms. Ideal for the experienced researcher as well as the novice, this informative book offers state-of-the-art reviews of all aspects of flow cytometry. New articles highlight investigations of higher plants, the flow cytometry of microorganisms, and measurements of intracellular ionized calcium and membrane potential--illustrating techniques of specimen preparation, measurement and analysis for each. New chapters examine applications of flow cytometry to medical genetics, genetic toxicology, and ultrasensitive analysis of molecules in solution. The Second Edition goes beyond the traditional analysis of DNA histograms with BrdU incorporation and DNA denaturability to identify and analyze the cell cycle more precisely. New or rewritten chapters discuss the importance of flow cytometry for measurements of nucleic acids, chromatin, and DNA and cover the cytometry of sperm and the cytopathic effects of viruses.
