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Provides a broad introduction to the subject of sleep. An overview of some of the classic and fundamental achievements in sleep research.
This volume contains the contributions to a course entitled "Sleep and its Pathology", which was organized by the Advanced School of the Italian Neuro science Society at the "Alessandro Volta" Center of Scientific Culture (Villa Olmo, Como, Italy, May 9-10,1996). The course was aimed at informing the medical audience about recent deve lopments in the field with particular regard to the work of the sleep laboratories of the University of Bologna. The first part of this book presents experimental results dealing with the bio chemical specificity of hypothalamic sleep mechanisms, cerebral metabolism during sleep and the sleep-dependent systemic cardiovascular adjustments in relation to blood pe...
This book aims at presenting biologists and clinicians with a compact description of the physiological manifestations of sleep that are significant from the viewpoint of the principle of homeostasis. In the jargon of the physiological literature, the word ?homeostasis?, introduced by W.B. Cannon (1926), refers to the existence of a constant state of extracellular body fluids with regard to their physical and chemical properties. Since normal cell function depends on the constancy of such fluids, in multicellular animals there are many regulatory mechanisms under the control of the central nervous system that act to maintain the constancy of the internal environment.The experimental study of ...
Spanning over half a century of investigation into Rapid Eye Movement (REM) sleep, this volume provides comprehensive coverage of a broad range of topics in REM sleep biology. World renowned researchers and experts are brought together to discuss past and current research and to set the foundation for future developments. Key topics are covered in six sections from fundamental topics (historical context and general biology) to cutting-edge research on neuronal regulation, neuroanatomy and neurochemistry, functional significance and disturbance in the REM sleep generating mechanism. A reference source for all aspects of REM sleep research, it also incorporates chapters on neural modelling, findings from non-human species and interactions between brain regions. This is an invaluable resource, essential reading for all involved in sleep research and clinical practice.
Easy to read and richly illustrated, Atlas of Clinical Sleep Medicine, 3rd Edition, provides the tools you need to accurately diagnose and treat the full range of adult and pediatric sleep disorders. Dr. Meir H. Kryger and a team of expert contributing authors detail the physiologic, clinical, morphologic, and investigational aspects of the sleep disorders you encounter in everyday practice—enhanced by high-quality images throughout. This highly regarded, award-winning atlas is an ideal resource for sleep practitioners and technicians in the lab, as well as an effective review for certification and recertification. - Features a thoroughly illustrated, reader-friendly format that highlights...
The Auditory System in Sleep presents for the first time a view of a sensory system working in a different state-that of the sleeping brain. The auditory system is always "open receiving information from the environment and the body itself (conscious and unconscious data). Even during sleep the auditory information is processed, although in a different way. This book draws information from evoked potentials, fMRI, PET, SPECT, lesions, etc., together with electrophysiological online data in order to depict how the auditory system single unit activity, recorded during sleep, revealed the possibility of sensory information participation in sleep processes. - Presents diverse experimental viewpoints from the beginning of classical electroencephalography to the more recent imaging, single units, electro-magneto-encephalography studies, etc. - Includes classic data as well as new data based in the existing literature and on the long scientific research lines (auditory and sleep) developed by the author and coworkers on this subject since 1963
J ÜRGEN AscHOFF "Very bad habit! Very bad habit!" Captain Giles to Joseph Conrad who had taken a siesta. -Conrad: The Shadow Line On the Multiplicity of Rest-Activity Cycles: Some Historical and Conceptual Notes According to its title this book tries to answer the profound question of why we nap-and why Captain Giles was wrong in blaming Conrad for having napped. However, in this volume the term nap is not used in the narrower sense of an afternoon siesta; instead, emphasis is placed on the recurrent alternation between states of alertness and drowsiness, i. e. , on rest-activity cycles of high er frequency throughout the 24 hr. In view of this focus, two authors (Stampi, in Chapter I, and ...
This edited volume records the critical historical developments in thermal physiology and makes them accessible to new and senior thermal biologists and scientists in related fields. Readers will discover how the discipline developed all over the world. Contributions from 14 different countries recollect all prominent discoveries, starting in the 18th century. Like other volumes of the Perspectives in Physiology series, this book reveals the people behind these discoveries. The authors also set the scenes in which the research was conducted in their countries. From geopolitical frameworks to new technologies and extraordinary personalities - this volume shows that scientific progress is influenced by many, often unforeseeable, factors. The history of thermal physiology not only is a story about individual outstanding scientists, but a testament for open collaboration and international comradery.
Following reviews on sleep physiology, regulation, pharmacology, and the neuronal networks regulating sleep and awakening, as well as a classification of sleep disorders, this book presents a number of major breakthroughs in the treatment of those disorders. These include recently approved drugs for treating insomnia, such as Doxepin; variations on previously approved molecules, e.g. Zolpidem sublingual preparation; or new chemical entities in advanced stages of clinical development, e.g. Orexin antagonists. Further topics discussed include drugs acting on the GABA receptor, such as Lorediplon and Eszopiclone; the treatment of excessive daytime drowsiness with cell therapy and drugs such as Modafinil, Armodafinil and Sodium oxybate; and the use of Tasimelteon in the treatment of circadian sleep disorders.
ROBERT WILLIAM McCARLEY Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School, Boston, and Brockton V A Medical Center, Brockton, Massachusetts The alternation of waking and sleeping, the daily course of the ad vancing and receding tides of consciousness, has long been a familiar part of our experience. But it is a new idea that autonomic and respiratory phys iology are equally and dramatically altered in a parallel fashion, and it is this concept that is summarized and developed here. The editors have drawn together thematically related chapters written by researchers with direct experience and a high level of expertise in the areas they address. The main theme is the...