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Beyond PD-1: novel checkpoint receptors and ligands as targets for immunotherapy
The incredible power of the immune system to control or eliminate neoplasias has been made evident by the success of immune checkpoint inhibitors (ICI). While inhibitory checkpoint receptors are critical for the maintenance of hemostasis under physiological conditions, dysregulation in the tumor microenvironment perturbs the role of these molecules with the promotion of exhausted cytotoxic cells, that is cytotoxic cells that no longer are able to control tumors. ICI leverages these targets to redirect cytotoxic responses and neutralize the suppressive tumor microenvironment. However, not all tumor types or patients respond to these therapies. Great interest continues to be focussed on first-generation ICI therapy (PD-1/PD-L1 and CTLA-4) but the potential for other targets and ligands remains vast.
Radiotherapy of Liver Cancer
This book provides up-to-date information on all aspects of radiotherapy for liver cancer, from the basic science to clinical practice. While demand for radiotherapy of liver cancer has been increasing, the guidance available to clinicians has remained limited. Radiotherapy of Liver Cancer aims to address this deficit on the basis of the best available evidence. The first two sections explain the relevant basic science and present detailed information on the available technologies and techniques, including the most recent advances. The radiotherapy strategies appropriate in different patient groups are then fully described, covering the use of ablative, adjuvant, neoadjuvant, and definitive radiotherapy, radiotherapy as a bridge to liver transplantation, and palliative radiotherapy. The final section addresses a range of specific issues of concern to the clinician. Radiotherapy of Liver Cancer will be an ideal reference for clinical radiation oncologists, radiation oncology residents, oncologists, and hepatologists.
The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents
This is a single volume, comprehensive book sanctioned by the American College of Laboratory Animal Medicine (ACLAM), covering the rabbit, guinea pig, hamster, gerbil and other rodents often used in research. This well illustrated reference includes basic biology, anatomy, physiology, behavior, infectious and noninfectious diseases, husbandry and breeding, common experimental methods, and use of the species as a research model. It is a resource for advancements in the humane and responsible care of: rabbit, guinea pig, hamster, gerbil, chinchilla, deer mouse, kangaroo rat, cotton rat, sand rat, and degu Includes up-to-date, common experimental methods. Organized by species for easy access during bench research.
Functional Molecular Gels
Written by active researchers in the area, this book details the latest research on the field from fundamentals to applications.
Using Animal Models In Biomedical Research: A Primer For The Investigator
Animal models play crucial roles in the continuum of experimental activities that make up biomedical research. Such in vivo modes are especially important in proof-of-principle experiments and in establishing the preclinical safety and efficacy data required for progressing to human clinical trials. A practical understanding of the choice, care and use of animal models is thus expected and required of all biomedical researchers. However, while both legislations and the practice of laboratory animal science have made great advances in the last decade and have impacted significantly on the use of animal models, this corpus of knowledge is not readily available in formats easily digestible to the average biomedical researcher. This book fills this gap in knowledge and provides material not easily sourced by the average biomedical researcher, such as current information on bioimaging, occupational health and biosafety, animal protocol design and histological-pathological support.
Help is just a click away: Social Network Sites and Support for Parents of Children with Special Needs
Feeling alone, searching for help, searching for a sense of belonging and identity: parents of children with special needs face various difficulties in their daily lives. But help and support can be extremely hard to obtain for these parents since they are limited by resources, location and time. However, things started to change when the World Wide Web began to connect people together. We now live in an era when networks of power can be achieved and maintained through virtual connections on the internet, where instant communication can be a form of power. This book hopes to shed light on how the simple act of “clicking” can empower (and, contrariwise, in some cases, disempower) parents ...
