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New Insights into Autoinflammatory Diseases: From Bench to Bedside
Systemic autoinflammatory diseases (SAIDs) are a growing group of rare disorders caused by dysregulation of the innate immune system leading to episodes of organ-specific and systemic inflammation. Autoinflammation as a distinct disease category was first reported in 1999 as a group of monogenic disorders with resultant activation of the inflammasome and cytokine excess, presenting as periodic fever and inflammation in serous membranes. Since this original description, the focus has shifted considerably to the inclusion of complex multifactorial conditions, and more than 30 associated genes have been identified. Disease severity varies from mild to life threatening. Advances in the understanding of the pathogenetic role of interleukin-1, have opened new promising horizons in the treatment of these patients, and significantly altered disease outcome.
Sjögren’s Syndrome: Pathogenicity, Novel targets and Antigens.
Dr. Baer is the site PI for a clinical trial investigating treatments related to Sjogren’s Syndrome, in conjunction with Viela Bio. The other Topic Editors declare no competing interests with relation to the topic theme.
IL-1 Inhibition
This special article collection of Frontiers in Pharmacology includes reviews and original articles on different aspects of IL-1 inhibition. Since the time IL-1 and its natural antagonist IL-1Ra have been discovered, specific IL-1 targeted therapies have been developed to cure an increasing number of diseases. The purpose of this Research Topic is to provide an overview of the different clinical uses of IL-1 blockade and new insights in basic research issues.
Imaging of Rheumatology, An Issue of Radiologic Clinics of North America
This issue of Radiologic Clinics of North America focuses on Imaging of Rheumatology, and is edited by Dr. Giuseppe Guglielmi. Articles will include: What the Rheumatologist is Looking For and What the Radiologist Should Know; Conventional Radiology in Rheumatoid Arthritis; Conventional Radiology in Spondyloarthritis; Conventional Radiology in Crystal Arthritis: Gout, Calcium Pyrophosphate Deposition, and Basic Calcium Phosphate Crystals; Ultrasound in Arthritis; Computed Tomography and Magnetic Resonance Imaging in Rheumatoid Arthritis; Computed Tomography and Magnetic Resonance Imaging in Spondyloarthritis; Computed Tomography and Magnetic Resonance Imaging in Crystal Arthritis; SAPHO and Recurrent Multifocal Osteomyelitis; Paediatric Vasculitis; Myopathies; Juvenile Arthritis and Other Pediatric Rheumatologic Disorders; Imaging of Post-Traumatic Arthritis, Aseptic Necrosis, Septic Arthritis, Sudek's Osteodystrophy, and Cancer Mimicking Arthritis; Imaging in Osteoarthritis; Interventions and Therapy in Rheumatology, and more!
Autoimmunity, COVID-19, Post-COVID19 Syndrome and COVID-19 Vaccination
Autoimmunity, COVID-19, Post-COVID-19 Syndrome and COVID-19 Vaccination covers all aspects of what is perhaps the most dramatic health crisis in the history of modern medicine. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raised major concerns about the association between the virus and various autoimmune manifestations. Over 15 distinct autoantibodies and above 10 different autoimmune diseases were found to develop in COVID-19 patients. Moreover, evidence about recovered COVID-19 patients demonstrates that persistent systemic symptoms, which are believed to have an autoimmune-related mechanism, do exist. As it is of great importance to recognize those autoimmune manifestatio...
