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Intermediate Filament Cytoskeleton
Intermediate filaments are a large family of proteins that are the cytoskeletal elements involved in a number of skin, liver, neuromuscular, cardiac, eye and hair diseases. Intermediate filament genes are regulated in a tissue-and cell type-specific manner and their polymerized protein products protects the cells and tissue they are part of against a variety of mechanical and nonmechanical stresses. This book provides a comprehensive resource of methodology essentials, describing a variety of essential tools and assays for studying intermediate filaments. The book provides user-friendly advice and protocols covering all aspects of intermediate filaments including protein isolation and struct...
The Cytoskeleton
The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. It comprises three major filament systems-actin, microtubules, and intermediate filaments-along with a host of adaptors, regulators, molecular motors, and additional structural proteins. This textbook presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture. It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. The book is thus essential reading for students learning about intracellular structure. It also represents a vital reference for all cell and developmental biologists working in this field.
Multinational Democracies
In this book, political scientists provide a collaborative study of multinational democracies and the difficulties in governing them.
Annual Report
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Manpower Planning and Organization Design
This volume is the proceedings of the conference entitled "Manpower Planning and Organization Design" which was held in Stresa, Italy, 20-24 June 1977. The Conference was sponsored by the NATO Scientific Affairs Division and organized jointly through the Special Programs Panels on Human Factors and on Systems Science. Two Conference Directors were appointed with overall responsibilities for the programme and for policy, and they were assisted in their tasks by a small advisory panel consisting of Professor A. Charnes (University of Texas), Professor W.W. Cooper (Carnegie Mellon University, now at Harvard University) and Dr. F.A. Heller (TavistQck Institute of Human Relations). Professor R. F...
In Defense of Mohawk Land
During 1990, a land dispute between the Mohawk territory of Kanehsatake and the town of Oka, Quebec, Canada took center stage in the world community, erupting into months of intense and often violent confrontation. Rooted in the historical reality of past injustices, the events of the 1990 Mohawk-Oka conflict epitomized the relationship and struggles which exists between Aboriginal nations, ethnonationalist movements, and the state. By examining the Mohawk-Oka conflict, this book tells a story of struggle and survival during the 1990 invasion by the Quebec provincial police and Canadian army into Mohawk sovereign land. The story is one of an embattled nation's struggle and aboriginal right to determine its political and economic destiny. Through extensive research of archived documents, newspapers, and interviews with leaders and members of the Mohawk Warrior Movement and other central figures in the Mohawk nation, the author demonstrates how politicized ethnicity and ideology can become significant factors in the repertoire of indigenous ethno-nationalist social movements for generating and maintaining social protest.
