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The Hsp70 Molecular Chaperone Machines
Members of the HSP70 family form a central hub of the molecular chaperone network, controlling protein homeostasis in prokaryotes and in the ATP-containing compartments of the eukaryotic cells. The heat-inducible form HSPA1A (HSP70), its constitutive cytosolic cognate HSPA8 (Hsc70), its endoplasmic reticulum form HSPA5 (BiP), and its mitochondrial form HSPA9 (Mortalin), as well as the more distantly related HSPHs (HSP110s), make up 1-2 % of the total mass of proteins in human cells. They use the energy of ATP-hydrolysis to prevent and forcefully revert the process of protein misfolding and aggregation during and following various stresses, presumably by working as unfoldases to lift aberrant...
Medicinal and Aromatic Plants of the Middle-East
The current volume, "Medicinal and Aromatic Plants of the Middle-East" brings together chapters on selected, unique medicinal plants of this region, known to man since biblical times. Written by leading researchers and scientists, this volume covers both domesticated crops and wild plants with great potential for cultivation. Some of these plants are well-known medicinally, such as opium poppy and khat, while others such as apharsemon and citron have both ritual and medicinal uses. All have specific and valuable uses in modern society. As such, it is an important contribution to the growing field of medicinal and aromatic plants. This volume is intended to bring the latest research to the attention of the broad range of botanists, ethnopharmacists, biochemists, plant and animal physiologists and others who will benefit from the information gathered therein. Plants know no political boundaries, and bringing specific folklore to general medical awareness can only be for the benefit of all.
Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks
This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.
Functions and Mechanisms of Bacterial Protein Homeostasis and Stress Responses
The Cover Image for This Research Topic is Used With Permission of the Authors and Publishers of the Following Article: Winkler J, Seybert A, König L, Pruggnaller S, Haselmann U, Sourjik V, Weiss M, Frangakis AS, Mogk A, Bukau B.EMBO J. 2010 Mar 3;29(5):910-23. doi: 10.1038/emboj.2009.412. Epub 2010 Jan 21
Ecophysiology and Biochemistry of Cyanobacteria
This book emphasizes and presents the latest information on eco-physiology and biochemistry of cyanobacteria with special emphasis on their biodiversity, molecular mechanisms of some important biological processes and survival mechanisms under myriad of environmental conditions as well as bioremediation. Cyanobacteria are the most dominant prokaryotic floras on the Earth’s surface, and are of great importance in terms of ecological, economical and evolutionary perspectives. They are oldest groups of photosynthetic autotrophs, which create oxygenic atmosphere for the development and sustainability of ecosystems with different life forms. The book presents an integrative approach to their po...
The Molecule Hunt
A leading expert at the forefront of bio-archaeology explains how this pioneering science is rewriting human history and unlocking stories of the past that could never have been told before.
Maize
This book examines one of the thorniest problems of ancient American archaeology: the origins and domestication of maize. Using a variety of scientific techniques, Duccio Bonavia explores the development of maize, its adaptation to varying climates and its fundamental role in ancient American cultures. An appendix (by Alexander Grobman) provides the first-ever comprehensive compilation of maize genetic data, correlating this data with the archaeological evidence presented throughout the book. This book provides a unique interpretation of questions of dating and evolution, supported by extensive data, following the spread of maize from South to North America and eventually to Europe and beyond.
Stress Proteins
All living organisms are exposed to rapidly changing environmental conditions which may lead to external stress. How organisms cope with stress - especially on the molecular level - is explained in Stress Proteins. Cells react to external stress - where the temperature-induced reaction known as "heat shock response" is the best studied example of stress - by activating special genes and subsequently synthesizing stress proteins. Surprisingly, this stress response is not only similar for all types of stress but even the involved stress proteins are virtually identical in all organisms from prokaryotic to eukaryotic cells, from bacteria to humans. This universality shows that stress proteins are vital for surviving and indicates that these proteins play an essential role in normal cell functions, in cell growth and metabolism. This explains the great interest in stress response research.
Molecular Chaperones and Neurodegeneration
Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered and several molecular mechanisms have been elucidated for many chaperones, while the field is being continuously challenged by new open questions. Probably as a consequence of the increasing research on the molecular bases of neurodegenerative diseases, and the realisation that many such disorders are linked to protein misfolding processes, unleashing the roles and mechanisms of chaperones in the context of neurodegeneration has become a prime scientific goal. This e-book contains a diversity of reviews, perspective and original research articles highlighting the importance and potential of this emerging subject.
Unlocking the Past
In Unlocking the Past, Martin Jones, a leading expert at the forefront of bioarchaeology—the discipline that gave Michael Crichton the premise for Jurassic Park—explains how this pioneering science is rewriting human history and unlocking stories of the past that could never have been told before. For the first time, the building blocks of ancient life—DNA, proteins, and fats that have long been trapped in fossils and earth and rock—have become widely accessible to science. Working at the cutting edge of genetic and other molecular technologies, researchers have been probing the remains of these ancient biomolecules in human skeletons, sediments and fossilized plants, dinosaur bones,...
