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An estimated 40 million Americans and millions of others worldwide suffer from some type of sleep disruption or disorder, and these numbers are rapidly increasing. As biomedical technologies advance our understanding of sleep, a wave of developments in sleep research and the emergence of new technologies offer hope and help for a good night’s sleep. Sleep: Circuits and Functions discusses the major discoveries related to the circuits responsible for slow wave sleep, REM sleep, narcolepsy, and the possible role of sleep in memory and developmental processes. World-renowned researcher Pierre-Hervé Luppi and a panel of expert contributors highlight advances in sleep research obtained by means of promising technologies. Data obtained by differential gene expression analysis, transgenic mice, and functional imaging is presented, as well as theoretical concepts on the mechanisms regulating sleep. Updating our knowledge of the strides made in sleep research, this comprehensive book also identifies future research opportunities in this growing field. It is an essential resource for medical professionals and researchers who aim to finally put sleep disorders to bed.
There has been a rapid global increase in the number of individuals making sleep medicine their career, resulting in an explosive growth in the number of sleep centres and programmes, as well as an increasing number of sleep societies and journals. Part of the Oxford Textbooks in Clinical Neurology series, the Oxford Textbook of Sleep Disorders covers the rapid advances in scientific, technical, clinical, and therapeutic aspects of sleep medicine which have captivated sleep scientists and clinicians. This text aims to introduce sleep disorders within the context of classical neurological diseases, giving an in-depth coverage of the topic in a logical and orderly way, while emphasizing the pr...
This book focuses on the neuropsychopharmacology of serotonin and its role in sleep and wakefulness, presenting neurochemical, electrophysiological, and neuropharmacological approaches to understand the mechanisms of serotonin and related substances. Covering core and contemporary topics in the area, this volume is valuable for all researchers interested in interdisciplinary studies concerning drugs affecting the central nervous system.
Handbook of Behavioral State Control: Cellular and Molecular Mechanisms provides the first synthesis of information on the neurobiology of behavioral states, ranging from normal stress and sleep deprivation to debilitating neuropsychiatric disorders. This book presents a working reference on the cellular and molecular mechanisms generating arousal states; pharmacological and non-pharmacological methods of behavioral state control; and the bi-directional interaction between arousal state and the neurobiology of pain, and between sleep and the immune system.
This volume connects current ideas and concepts about sleep functions and circadian rhythms with the search for novel target-selective sleep-wake therapeutics. To do so, it provides a timely, state-of-the-art overview of sleep-wake mechanisms in health and disease, ongoing developments in drug discovery, and their prospects for the clinical treatment of sleep-disordered patients. It particularly focuses on the concept that sleep and wakefulness mutually affect each other, and the future therapeutic interventions with either sleep- or wake-promoting agents that are expected to not only improve the quality of sleep but also the waking behavior, cognition, mood and other sleep-associated physiological functions. The chapter 'Sleep Physiology, Circadian Rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics' available open access under a CC BY 4.0 license at link.springer.com
Spanning over half a century of investigation into Rapid Eye Movement (REM) sleep, this volume provides comprehensive coverage of a broad range of topics in REM sleep biology. World renowned researchers and experts are brought together to discuss past and current research and to set the foundation for future developments. Key topics are covered in six sections from fundamental topics (historical context and general biology) to cutting-edge research on neuronal regulation, neuroanatomy and neurochemistry, functional significance and disturbance in the REM sleep generating mechanism. A reference source for all aspects of REM sleep research, it also incorporates chapters on neural modelling, findings from non-human species and interactions between brain regions. This is an invaluable resource, essential reading for all involved in sleep research and clinical practice.
Proceedings of the International Symposium on Integrative and Cellular Aspects of Autonomic Functions Held in Bad Nauheim (Germany) on 29-30 July 1993.
Sleep Disorders II covers various aspects of sleep disorders. These include the different classification of sleep disorders, the genetic influences of sleep disorders, abnormality in the sleeping pattern, and the circadian rhythm sleep disorder. A sleep disorder is a medical disorder that affects the sleeping patterns of humans (and sometimes animals). The disruptions in sleep can be caused by different factors, such as teeth grinding, night terrors, and the like. The book also discusses different perspectives on insomnia and hypersomnia. According to the International Classification of Sleep Disorders, insomnia is a sleep that is low in quality or a difficulty in sleeping. On the other hand...
Having examined previous volumes of the Boston Studies series devoted to different countries, and having discussed the best way to present contemporary research in France, we have arrived at a careful selection of 15 participants, including the organizers. Our aim is to bring together philosophers and practicing scientist from the major institutions of the country, both universities and research centers. The areas of research represented here cover a wide spectrum of sciences, from mathematics and physics to the life sciences, as well as linguistics and economics. This selection is a showcase of French philosophy of science, illustrating the different methods employed: logico-linguistic analysis, rational reconstruction and historical inquiry. These participants have the ability to relate their research both to the French tradition and current discussions on the international scene. Also included is a substantial historical introduction, explaining the development of philosophy of science in France, the various schools of thought and methods as well as the major concepts and their significance.
The second part of a two-part work in the Handbook of Clinical Neurology series on sleep disorders.