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This fully updated volume explores N-Methyl-D-aspartate receptors (NMDARs), and the structure-function relations, principles, and rules that govern how NMDARs operate in brain processing under normal and pathological conditions. With chapters from leading laboratories around the world, this book examines the expression and purification of diverse NMDA receptor subtypes, gene targeting and generation of conditional NMDAR mutant mouse lines, studies of NMDARs in zebrafish, electrophysiological studies, NMDARs modeling in silico, drug development with artificial intelligence, and much more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, NMDA Receptors: Methods and Protocols, Second Edition serves as an ideal guide to the diversity of possible approaches in the field of NMDARs and the progress that has been made in recent years.
In the last years, clinical data, neurophysiological and imaging investigations, as well as genetic studies have renewed the interest on ESES. In addition, experimental findings from sleep research have opened fascinating perspectives on some possible pathophysiological mechanisms involved in this condition. These issues are presented and discussed in this book by clinicians, neurophysiologists, sleep physiologists and geneticists. They all have been working on ESES with the aim to provide an updated overview of this special syndrome in the light of recent research.
Book and DVD. The fourth edition of Epileptic syndromes in Infancy, Childhood and Adolescence is based on the syndromic approach to epilepsy that is the trademark of the Marseille School of European epileptology, including new perspectives. The accompanying DVD includes video sequences of the various syndromes.
This topic has been realized in collaboration with Dr. Gabriele Ruffolo, Post Doctoral Researcher at the University of Rome (Sapienza) (ORCID ID: 0000-0002-6554-5496).
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Este libro ofrece una oportuna y magistral descripción de los aspectos clínicos y electrofisiológicos de las epilepsias benignas en lactantes, niños y adolescentes, comenzando con la epilepsia benigna de la niñez con espigas centrotemporales, que fue la primera en describirse y sigue siendo la forma más conocida y frecuente. Desde entonces, se fueron agregando muchos otros tipos, y el lector encontrará una exhaustiva y profunda revisión de los múltiples síndromes con una actualización completa de los datos hasta ahora publicados. Se pone especial énfasis en la forma benigna de epilepsia occipital, dado que aún se la reconoce en menor medida a pesar de que también es relativamen...