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The Carlsberg Story
This book offers a comprehensive business history of one of the largest global brewing companies. By combining industrial history with insights from corporate management and strategy, it reveals the success story of a family-owned company that has achieved a market-leading position worldwide. The author provides deep insights into the founding of the modern Danish brewery by J.C. Jacobsen Carlsberg in 1847, the company’s subsequent rapid success, the relationship between brewing and science, and the importance of the Danish scientist H.C. Ørsted in establishing this relationship. Readers will also learn about the founder’s son, Carl Jacobsen, and the tensions between him and his father;...
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Global Marine Science and Carlsberg - The Golden Connections of Johannes Schmidt (1877-1933)
By accident, the world-famous brewery Carlsberg became a central force in global marine science during the first three decades of the 20th century. Within a core group of scientists and managers, Johannes Schmidt (1877-1933) was the key figure combining the efforts of the International Council for the Exploration of the Sea (ICES), the Danish state and several private companies. Launching 26 oceangoing expeditions Schmidt made landmark discoveries such as the breeding ground for the Atlantic eel in the Sargasso Sea. The scientific frontier was pushed literally kilometres into the deep sea and across the World’s oceans. While the formal North Atlantic Empire of the small state of Denmark was in decline, an informal empire of science was erected instead. Shortlisted for the Society for Nautical Research Anderson Medal for published works on Maritime History in 2016.
Textbook of Drug Design and Discovery, Third Edition
Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.
QSAR
Finding the new remedy for a certain disease: an inspired goal. QSAR, an invaluable tool in drug design, aids scientists to attain this aim. This book is a long-awaited comprehensive text to QSAR and related approaches. It provides a practice-oriented introduction to the theory, methods and analyses for QSAR relationships, including modelling-based and 3D approaches. Hugo Kubinyi is a leading expert in QSAR. Readers will benefit from the author's 20 years of practical experience, from his careful calculations and recalculations of thousands of QSAR equations. Among the topics covered are: - physiocochemical parameters - quantitative models - statistical methods - Hansch analysis - Free Wilson analysis - 3D-QSAR approaches The book can readily be used as a textbook due to its high didactic value and numerous examples (over 200 equations and 1100 references).
Plasticity and Regeneration of the Nervous System
Proceedings of the Third Conference of the Institute of Developmental Neuroscience and Aging, held in Torino, Italy, April 5-7, 1990
Chemistry and Molecular Aspects of Drug Design and Action
An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to deve
Chemometric Methods in Molecular Design
The statistical analysis of experimental and theoretical data lies at the heart of modern drug design. This practice-oriented handbook is a comprehensive account of modern chemometric methods in molecular design. It presents strategies for making more rational choices in the planning of syntheses, and describes techniques for analyzing biological and chemical data. Written by the world's experts, it provides in-depth information on * molecular concepts * experimental design in the planning of syntheses * multivariate analysis of chemical and biological data * statistical validation of QSAR results An additional benefit: the book contains a critical survey of commercially available software packages both for statistical analysis as well as for special applications. Industrial and academic researches in medicinal chemistry and organic chemistry will value this book as a useful source of information for their daily work. Also available: Advanced Computer-Assisted Techniques in Drug Discovery, edited by H. van de Waterbeemd
Open Access Databases and Datasets for Drug Discovery
Open Access Databases and Datasets for Drug Discovery Timely resource discussing the future of data-driven drug discovery and the growing number of open-source databases With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike su...
