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Non-peptide Inhibitors of Proprotein Convertase Subtilisin Kexins (PCSKs)
The Ca+2-dependent mammalian Proprotein Convertase Subtilisin Kexins (PCSKs) or Proprotein/ Prohormone Convertases (PCs) are a family of endoproteases that play critical roles not only in normal development and metabolism but also in various physiological and pathological conditions. These were initiated by the proteolytic processing of large inactive proproteins into their shorter bioactive mature forms by the PCSK enzymes. These events take place in a highly selective, orchestrated, and stepwise manner. Among the various proprotein substrates of PCSK enzymes, particularly important are the precursor growth factors that include proPDGF-A, B, proIGF-1, 2 and proVEGF-C because of their strong...
The Proprotein Convertases
Proprotein convertases (PCs) are a family of proteases including PC1, PC2, Furin, PC4, PACE4, PC5, and PC7. These enzymes are involved in the maturation of many precursor proteins involved in the process of tumorigenesis and metastasis. Since their discovery, PCs were suggested as potential targets for anti-cancer therapy, and their activity was found to directly affect tumor cell proliferation, migration invasion, and the malignant phenotypes of tumor cells. Here, we discuss a number of previous and recent findings on the PCs features, their implication in the regulation of multiple cellular functions that impact on the invasive/metastatic potential of cancer cells, and their clinical relev...
IAP Colour Atlas of Pediatrics
Colour atlas pn paediatric illnesses and management covering both common and rare disorders.
Exploring Medical Biotechnology- in vivo, in vitro, in silico
This book on medical biotechnology offers a wide array of topics and cutting-edge research in the field featuring contributions from multiple authors, each specializing in their respective areas, making it highly valuable to science students and enthusiasts. The book provides comprehensive coverage on a diverse range of topics including sequence analysis, network pharmacology, drug discovery, CRISPR-Cas technology, precision medicine, neuroimaging biomarkers, therapeutics for neurodegenerative diseases, molecular pathogenesis of various diseases, plant-derived antioxidants, genetic approaches for disease diagnosis, cancer progression, immunotherapy, cancer biomarker identification, RNA Inter...
Advances in Data Science and Computing Technology
This volume helps to address the genuine 21st century need for advances in data science and computing technology. It provides an abundance of new research and studies on progressive and innovative technologies, including artificial intelligence, communication systems, cyber security applications, data analytics, Internet of Things (IoT), machine learning, power systems, VLSI, embedded systems, and much more. The book presents a variety of interesting and important aspects of data science and computing technologies and methodologies in a wide range of applications, including deep learning, DNA cryptography, classy fuzzy MPPT controller, driving assistance, and safety systems. Novel algorithms...
Proceedings of the 4th International Conference on Frontiers in Intelligent Computing: Theory and Applications (FICTA) 2015
The proceedings of the 4th International Conference on Frontiers in Intelligent Computing: Theory and Applications 2015 (FICTA 2015) serves as the knowledge centre not only for scientists and researchers in the field of intelligent computing but also for students of post-graduate level in various engineering disciplines. The book covers a comprehensive overview of the theory, methods, applications and tools of Intelligent Computing. Researchers are now working in interdisciplinary areas and the proceedings of FICTA 2015 plays a major role to accumulate those significant works in one arena. The chapters included in the proceedings inculcates both theoretical as well as practical aspects of different areas like Nature Inspired Algorithms, Fuzzy Systems, Data Mining, Signal Processing, Image processing, Text Processing, Wireless Sensor Networks, Network Security and Cellular Automata.
Digital Microfluidic Biochips
Digital Microfluidic Biochips focuses on the automated design and production of microfluidic-based biochips for large-scale bioassays and safety-critical applications. Bridging areas of electronic design automation with microfluidic biochip research, the authors present a system-level design automation framework that addresses key issues in the design, analysis, and testing of digital microfluidic biochips. The book describes a new generation of microfluidic biochips with more complex designs that offer dynamic reconfigurability, system scalability, system integration, and defect tolerance. Part I describes a unified design methodology that targets design optimization under resource constrai...
Prebiotics, Probiotics and Nutraceuticals
The book titled ‘Prebiotics, Probiotics and Nutraceuticals’ is expected to direct many emerging research pathwaysneed at local and global levels for nutrition and food supplements for developing immunity for healthy life. This volume incorporates sixteen seminal papers on issue based research and their practical applications covering latest information and progress on different area of nutritional supplement research fight against disease. The book highlights the frontier issues and applications in nutritional biotechnology with wide coverage of the themes like Potentiality of Probiotics in Inactivation of Tetrodotoxin, Therapeutic Strategy for the Deterrence of COVID-19 with Relevance t...
