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Journey of Perseverance
In the 'Journey of Perseverance' Priya Mishra recounts how she tore through all odds to become the leader that she is today. With powerful learning’s and messages across every page, the author has infused several personal examples of perseverance that can be used in our daily lives. She strongly paints a picture of culture and how a culturally conditioned individual can achieve the unthinkable with the right kind of support from other members.
Non-peptide Inhibitors of Proprotein Convertase Subtilisin Kexins (PCSKs)
The Ca+2-dependent mammalian Proprotein Convertase Subtilisin Kexins (PCSKs) or Proprotein/ Prohormone Convertases (PCs) are a family of endoproteases that play critical roles not only in normal development and metabolism but also in various physiological and pathological conditions. These were initiated by the proteolytic processing of large inactive proproteins into their shorter bioactive mature forms by the PCSK enzymes. These events take place in a highly selective, orchestrated, and stepwise manner. Among the various proprotein substrates of PCSK enzymes, particularly important are the precursor growth factors that include proPDGF-A, B, proIGF-1, 2 and proVEGF-C because of their strong...
The Proprotein Convertases
Proprotein convertases (PCs) are a family of proteases including PC1, PC2, Furin, PC4, PACE4, PC5, and PC7. These enzymes are involved in the maturation of many precursor proteins involved in the process of tumorigenesis and metastasis. Since their discovery, PCs were suggested as potential targets for anti-cancer therapy, and their activity was found to directly affect tumor cell proliferation, migration invasion, and the malignant phenotypes of tumor cells. Here, we discuss a number of previous and recent findings on the PCs features, their implication in the regulation of multiple cellular functions that impact on the invasive/metastatic potential of cancer cells, and their clinical relev...
Orissa Gazette
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Art and Culture of Orissa
This book highlights the colourful vista of art and culture of Orissa in a simple and lucid language with supporting illustrations.
Mainstream
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